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Purified anti-human CD89 Antibody

Pricing & Availability
Clone
A59 (See other available formats)
Regulatory Status
RUO
Workshop
V MR30
Other Names
FcαR
Isotype
Mouse IgG1, κ
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Product Citations
publications
A59_Purified_CD89_Antibody_FC_112912
Human peripheral blood granulocytes were stained with purified anti-human CD89 (clone A59, filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG FITC.
  • A59_Purified_CD89_Antibody_FC_112912
    Human peripheral blood granulocytes were stained with purified anti-human CD89 (clone A59, filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG FITC.
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354102 100 µg 108€
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Cat. No. 354101 has been discontinued. Please see larger size as its alternative.
Description

CD89, also known as FcαR, is a 55-100 kD glycosylated protein.  It belongs to the immunoglobulin gene family.  It is expressed on granulocytes, monocytes, and macrophages but is absent on T cells.  It can interact with IgA aggregates and plays an important role in IgA mediated immune responses.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Ag8.653 myeloma cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References
  1. Monteiro RC, et al. 1992. J. Immunol. 148:1764.
  2. Shen L. 1992. J. Leukoc. Biol. 51:373.
  3. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
  4. Rogers KA, et al. 2004. Immunology 113:178.
Product Citations
  1. Alcántara-Hernández M, et al. 2021. Nat Protoc. 16:4855. PubMed
  2. Dutertre CA, et al. 2020. Immunity. 51(3):573-589.e8.. PubMed
RRID
AB_2561350 (BioLegend Cat. No. 354102)

Antigen Details

Structure
Member of the immunoglobulin gene family and is a transmembrane glycoprotein, 55-100 kD
Distribution

Granulocytes, neutrophils, eosinophils, monocytes, macrophages

Function
Interacts with IgA opsonized targets and induces immunological processes such as phagocytosis, ADCC, and release of inflammatory mediators
Ligand/Receptor
IgA (monomeric, dimeric, polymeric and secretory IgA)
Cell Type
Eosinophils, Granulocytes, Macrophages, Monocytes, Neutrophils
Biology Area
Immunology
Molecular Family
CD Molecules, Fc Receptors
Antigen References

1. Patry C, et al. 1996. J. Immunol. 156:4442.
2. de Wit, et al. 1995. J. Immunol. 155:1203.
3. Honorio-França AC, et al. 2001. J. Leukoc. Biol. 69:289.

Gene ID
2204 View all products for this Gene ID
UniProt
View information about CD89 on UniProt.org
Go To Top Version: 3    Revision Date: 08/15/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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