Purified anti-human CD18 Antibody anti-CD18

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Clone: 1B4/CD18 (See other available formats)
Regulatory Status: RUO
Other Names: Integrin beta-2, integrin beta chain, beta 2
Isotype: Mouse IgG2a, κ
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Product Citations: publications

1B4slashCD18_PURE_CD18_Antibody_022317 — Human peripheral blood lymphocytes were stained with purified CD18 (clone 1B4/CD18) (filled histogram) or purified mouse IgG2a, κ isotype control (open histogram) followed by PE Goat anti-mouse IgG.

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373402

100 µg

$112

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Description

CD18 is a 90-95 kD type I transmembrane protein also known as integrin β2 subunit, LFA-1 β subunit, and β2 integrin. CD18 non-covalently associates with CD11a, CD11b or CD11c. CD18 is expressed on all leukocytes. CD18 and associated α chains function in adhesion and signaling in hematopoietic cells.

Product Details

Technical data sheet

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human peripheral blood lymphocytes
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: The 1B4/CD18 antibody was able to partially block the Ts1/18 antibody, indicating the two anti-CD18 antibodies recognize distinct but overlapping epitopes.
RRID: AB_2650942 (BioLegend Cat. No. 373402)

Antigen Details

Structure: Integrin, type I transmembrane glycoprotein
Distribution: Leukocytes
Function: Adhesion and signaling in hematopoietic cells
Interaction: Associates with CD11a, CD11b, or CD11c
Ligand/Receptor: ICAMs
Cell Type: Leukocytes, Tregs
Biology Area: Cell Adhesion, Cell Biology, Immunology, Signal Transduction
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Hogg N, et al. 1999. J. Clin. Invest. 103:97.
2. Anderson DC, et al. 1987. Annu. Rev. Med. 38:175.
3. Springer TA. 1994. Cell 76:301.
Gene ID: 3689 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):: CD18
Specificity Alt (DOES NOT SHOW ON TDS):: CD18
App Abbreviation (DOES NOT SHOW ON TDS):: FC
UniProt: View information about CD18 on UniProt.org

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Other Formats

View All CD18 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human CD18	1B4/CD18	FC
APC anti-human CD18	1B4/CD18	FC
PE/Cyanine7 anti-human CD18	1B4/CD18	FC
Alexa Fluor® 488 anti-human CD18	1B4/CD18	FC
PE anti-human CD18	1B4/CD18	FC

Certificate of Analysis

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Go To Top Version: 0 Revision Date: 03/16/2017

For Research Use Only. Not for diagnostic or therapeutic use.

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