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APC anti-mouse CD159a (NKG2AB6) Antibody

Pricing & Availability
Clone
16A11 (See other available formats)
Regulatory Status
RUO
Other Names
KLRC1, NKG2B, NKG2AB6
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
16A11_APC_1_012612
C57BL/6 mouse splenocytes were stained with NK1.1 (clone PK136) PE and CD159a (NKG2AB6, clone 16A11, top) APC or mouse IgG2b, κ APC isotype control (bottom).
  • 16A11_APC_1_012612
    C57BL/6 mouse splenocytes were stained with NK1.1 (clone PK136) PE and CD159a (NKG2AB6, clone 16A11, top) APC or mouse IgG2b, κ APC isotype control (bottom).
  • 16A11_APC_2_012612
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142807 50 µg $131
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142808 200 µg $350
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Description

CD159a, also known as NKG2A or KLRC1 (killer cell lectin-like receptor subfamily C, member 1), is a 43 kD type II transmembrane protein with extracellular C-type lectin domains.  It belongs to the killer cell lectin-like receptor family also known as the NKG2 family.  It is expressed on NK and NKT cells and activated CD8+ T cells.  NKG2A binds to non-classical MHC class I molecule Qa-1 and causes inhibition of NK cell-mediated target-cell lysis. 

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
C57BL/6 mouse CD94/NKG2A transfected CHO cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

This product may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use licenses cannot be guaranteed from the University of California.

Application References

(PubMed link indicates BioLegend citation)
  1. McMahon CW, et al. 2002. J. Immunol. 169:1444. (FC)
  2. Vance RE, et al. 2002. P. Natl. Acad. Sci. USA 99:868. (FC)
Product Citations
  1. Aghayev T, et al. 2022. Cancer Discov. 12:1960. PubMed
  2. Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed
  3. Shreeve N, et al. 2021. Immunity. 54(6):1231-1244.e4. PubMed
RRID
AB_11124538 (BioLegend Cat. No. 142807)
AB_11124538 (BioLegend Cat. No. 142808)

Antigen Details

Structure
Type II transmembrane protein with extracelluar C-type lectin domains, complexed with CD94; 43 kD
Distribution

NK cells and NK T cells from C57BL/6 mouse

Function
Inhibitory activity via ITIMs
Ligand/Receptor
Non-classical MHC-I molecule Qa-1
Cell Type
Embryonic Stem Cells, Mesenchymal Stem Cells, NK cells, NKT cells
Biology Area
Cell Biology, Immunology, Signal Transduction, Stem Cells
Molecular Family
CD Molecules, MHC Antigens
Antigen References

1. Vance RE, et al. 1998. J Exp Med. 188:1841-8.
2. Lohwasser S, et al. 1999. Eur J Immunol. 29:755-61.
3. Sivakumar PV, et al. 1999. J Immunol. 162:6976-80.
4. Silver ET, et al. 1999. Immunogenetics 49:727-30.
5. Vance RE, et al. 1999. J Exp Med. 190:1801-12.

Gene ID
16641 View all products for this Gene ID
UniProt
View information about CD159a on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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