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Purified anti-human CD209 (DC-SIGN) Antibody

Pricing & Availability
Clone
A20120B (See other available formats)
Regulatory Status
RUO
Other Names
Dendritic Cell-Specific Intercellular adhesion molecule 3 (ICAM-3)-Grabbing Nonintegrin (DC-SIGN), CLEC4L, DC-SIGN, DC-SIGN1, hDC-SIGN
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
A20120B_PURE_CD209_Antibody_060622
Human monocyte-derived dendritic cells were stained with purified anti-human CD209 (DC-SIGN) (clone A20120B) (filled histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by PE goat-anti-rat IgG.
  • A20120B_PURE_CD209_Antibody_060622
    Human monocyte-derived dendritic cells were stained with purified anti-human CD209 (DC-SIGN) (clone A20120B) (filled histogram) or purified rat IgG2b, κ isotype control (open histogram), followed by PE goat-anti-rat IgG.
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380402 100 µg $258
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Description

CD209, known as Dendritic Cell-Specific Intercellular adhesion molecule 3 (ICAM-3)-Grabbing Nonintegrin (DC-SIGN), is a 44 kD type II transmembrane glycoprotein and a member of the C-type lectin family. CD209 is expressed on myeloid dendritic cells, placental macrophages, liver and placental endothelial cells. CD209 binds to ICAM-3 (CD50), ICAM-2 (CD102), and Butyrophilin (BTN2A1), and mediates dendritic cell migration and T cell proliferation. Importantly, CD209 is a receptor of HIV-1 and some other viruses (such as West Nile virus, hepatitis C virus, etc), and some bacteria or parasites. It plays a critical role in capturing and internalizing those pathogens. LSP1 (leukocyte-specific protein 1) interacts with the cytoplasmic domain of CD209 and mediates transport of HIV to the proteasome.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant human CD209 protein, extracellular domain.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone A20120B can partially block the binding of clone 9E9A8 to target. It does not affect the binding of clone DCS-8C1, clone A20120F, and clone 14E3G7.

RRID
AB_2924571 (BioLegend Cat. No. 380402)

Antigen Details

Structure
A 44 kD type II transmembrane glycoprotein and a member of the C-type lectin family
Distribution

Dendritic cells, Endothelial cells, Macrophages

Function
Functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus.
Cell Type
Dendritic cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References
  1. Fauci A. 1996. Nature. 384:529-34.
  2. Granelli-Piperno A, et al. 2005. J Immunol. 175:4265-73. 
  3. Lai WK, et al. 2006. Am J Pathol. 169:200-8.
Gene ID
30835 View all products for this Gene ID
UniProt
View information about CD209 on UniProt.org
Go To Top Version: 1    Revision Date: 06/06/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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