PE/Cyanine7 anti-human CD38 Antibody

Pricing & Availability
Clone
HIT2 (See other available formats)
Regulatory Status
RUO
Workshop
III 155
Other Names
T10, ADP-ribosyl cyclase
Isotype
Mouse IgG1, κ
HIT2_PECy7_021009.jpg
Human peripheral blood lymphocytes stained with HIT2 PE/Cyanine7
  • HIT2_PECy7_021009.jpg
    Human peripheral blood lymphocytes stained with HIT2 PE/Cyanine7
Compare all formats See PE/Cyanine7 spectral data
Cat # Size Price Quantity Check Availability
303515 25 tests $153.00
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303516 100 tests $311.00
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Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscles, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee, Horse, Cow
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections6 and spatial biology (IBEX)10,11.

Application References

(PubMed link indicates BioLegend citation)
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Dieu M. 1998. J. Exp. Med. 188:373.
  3. Esser M, et al. 2001. J. Virol. 75:6173.
  4. Jeannin P, et al. 1999. J. Immunol. 162:2044.
  5. Kapsogeorgou EK, et al. 2001. J. Immunol. 166:3107.
  6. van der Voort R, et al. 1997. J. Exp. Med. 185:2121. (IHC)
  7. Bende RJ, et al. 2003. Am. J. Pathol. 162:105.
  8. Lehner M, et al. 2008. J. Leukoc. Biol. 83:883. PubMed
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed
  11. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Fu J et al. 2019. Cell stem cell. 24(2):227-239 . PubMed
  2. Chen HY, et al. 2022. Elife. 11:. PubMed
  3. Parry H, et al. 2022. Cell Rep Med. 3:100739. PubMed
  4. Crees ZD, et al. 2023. Nat Med. 29:869. PubMed
  5. Kfoury Y, et al. 2021. Cancer Cell. 39:1464. PubMed
  6. Kuloglu ZE, et al. 2022. Allergy. 77:2459. PubMed
  7. Albayrak E, et al. 2022. J Cell Biochem. 123:2009. PubMed
  8. He T, et al. 2023. Immun Inflamm Dis. 11:e759. PubMed
  9. Tavor S, et al. 2020. Haematologica. . PubMed
  10. Shoda H, et al. 2017. Arthritis Research & Therapy . 10.1186/s13075-017-1308-y. PubMed
  11. Karim F, et al. 2021. Elife. 10:. PubMed
  12. Ishizaka A, et al. 2016. J Virol. 90: 5665 - 5676. PubMed
  13. Nagafuchi Y, et al. 2016. Sci Rep. 6:29338. PubMed
  14. Tsuchida Y, et al. 2017. PLoS One. 10.1371/journal.pone.0169646. PubMed
  15. Riether C, et al. 2021. Cell Reports. 34(4):108663. PubMed
  16. Chaimowitz N, et al. 2011. J Immunol. 187:5114. PubMed
  17. Turner JS, et al. 2021. Nature. 596:109. PubMed
  18. Boisson B, et al. 2015. J Exp Med. 212:939. PubMed
  19. Lal A, et al. 2021. Nat Commun. 1507:12. PubMed
  20. Huang M, et al. 2021. BMC Infect Dis. 21:922. PubMed
  21. Albayrak E, et al. 2021. J Cell Physiol. 236:8122. PubMed
  22. Amanat F, et al. 2021. Cell. 184:3936. PubMed
  23. , et al. 2020. Haematologica. 105:2795. PubMed
  24. Wang X, et al. 2021. Cell Discovery. 7(1):60. PubMed
  25. Hofmann M, et al. 2012. Leukemia. 26:1288. PubMed
  26. Audigé A, et al. 2017. BMC Immunology. 10.1186/s12865-017-0209-9. PubMed
  27. Turner JS, et al. 2020. Nature. 586:127. PubMed
  28. Okurut S, et al. 2020. Infect Immun. 88:. PubMed
  29. Setliff I, et al. 2018. Cell Host Microbe. 23:845. PubMed
  30. Isobe T, et al. 2022. Nat Commun. 13:4501. PubMed
  31. Hoffmann M, et al. 2016. PLoS Pathog. 12: 1005661. PubMed
  32. Singh A, et al. 2020. Cell Rep. 32:108153. PubMed
  33. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  34. Fu Y, et al. 2021. Cell Reports. 36(2):109344. PubMed
  35. Lorkova L, et al. 2015. PLoS One. 10: 0135314. PubMed
  36. Neu KE, et al. 2019. J Clin Invest. 129:93. PubMed
  37. Salazar-Camarena DC, et al. 2020. Sci Rep. 10:6236. PubMed
  38. Katsuyama E, et al. 2020. Cell Reports. 30(1):112-123.e4.. PubMed
  39. Weinberg A, et al. 2015. PLoS One. 10:122431. PubMed
  40. Inui M, et al. 2015. Int Immunol. 27: 345 - 355. PubMed
  41. S Tzeng 2016. J Vis Exp. 118:e54582. PubMed
  42. Dutta AK, et al. 2019. Leukemia. 33:457. PubMed
  43. Bhuiyan TR, et al. 2022. PLoS Negl Trop Dis. 16:e0010411. PubMed
  44. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  45. Shan L, et al. 2017. Immunity. 47:766. PubMed
  46. Chen PM, et al. 2022. Sci Adv. 8:eabo4271. PubMed
  47. Trivedi S, et al. 2020. Elife. 9:00. PubMed
RRID
AB_1279235 (BioLegend Cat. No. 303515)
AB_1279235 (BioLegend Cat. No. 303516)

Antigen Details

Structure
ADP-ribosyl cyclase, ectoenzyme, type II glycoprotein, 45 kD
Distribution

T cells, B cells, NK, myeloid, plasma, and dendritic cells

Function
Ecto-ADP-ribosyl cyclase, calcium signaling, cell activation
Ligand/Receptor
CD31, hyaluronic acid
Cell Type
B cells, Dendritic cells, NK cells, Plasma cells, T cells
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Ferrero E, et al. 1999. J. Leukoc. Biol. 65:151.
2. Lund F, et al. 1995. Immunol. Today 16:469.

Gene ID
952 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org

Other Formats

View All CD38 Reagents Request Custom Conjugation
Description Clone Applications
APC anti-human CD38 HIT2 FC
FITC anti-human CD38 HIT2 FC
PE anti-human CD38 HIT2 FC
PE/Cyanine5 anti-human CD38 HIT2 FC
Purified anti-human CD38 HIT2 FC,CyTOF®,IHC-F
Alexa Fluor® 488 anti-human CD38 HIT2 FC
Alexa Fluor® 647 anti-human CD38 HIT2 FC
PE/Cyanine7 anti-human CD38 HIT2 FC
Biotin anti-human CD38 HIT2 FC
PerCP anti-human CD38 HIT2 FC
PerCP/Cyanine5.5 anti-human CD38 HIT2 FC
Alexa Fluor® 700 anti-human CD38 HIT2 FC,SB
Brilliant Violet 421™ anti-human CD38 HIT2 FC
Brilliant Violet 711™ anti-human CD38 HIT2 FC
Brilliant Violet 785™ anti-human CD38 HIT2 FC
Brilliant Violet 605™ anti-human CD38 HIT2 FC
APC/Cyanine7 anti-human CD38 HIT2 FC
Purified anti-human CD38 (Maxpar® Ready) HIT2 FC,CyTOF®
PE/Dazzle™ 594 anti-human CD38 HIT2 FC
PE anti-human CD38 HIT2 FC
Brilliant Violet 510™ anti-human CD38 HIT2 FC
FITC anti-human CD38 HIT2 FC
PE/Dazzle™ 594 anti-human CD38 HIT2 FC
TotalSeq™-A0389 anti-human CD38 HIT2 PG
TotalSeq™-C0389 anti-human CD38 HIT2 PG
APC/Fire™ 750 anti-human CD38 HIT2 FC
TotalSeq™-B0389 anti-human CD38 HIT2 PG
APC/Fire™ 810 anti-human CD38 HIT2 FC
Spark NIR™ 685 anti-human CD38 Antibody HIT2 FC
TotalSeq™-D0389 anti-human CD38 HIT2 PG
PerCP/Cyanine5.5 anti-human CD38 HIT2 FC
APC anti-human CD38 HIT2 FC
APC/Fire™ 750 anti-human CD38 HIT2 FC
PE/Cyanine7 anti-human CD38 HIT2 FC
GMP PE anti-human CD38 HIT2 FC
GMP FITC anti-human CD38 HIT2 FC
Pacific Blue™ anti-human CD38 HIT2 FC
Pacific Blue™ anti-human CD38 HIT2 FC
GMP APC/Fire™ 750 anti-human CD38 HIT2 FC
GMP PE/Dazzle™ 594 anti-human CD38 HIT2 FC
GMP APC anti-human CD38 HIT2 FC
GMP PE/Cyanine7 anti-human CD38 HIT2 FC
Spark Blue™ 515 anti-human CD38 HIT2 FC
GMP Pacific Blue™ anti-human CD38 HIT2 FC
Spark Violet™ 423 anti-human CD38 HIT2 FC
Brilliant Violet 650™ anti-human CD38 HIT2 FC
Spark PLUS B550™ anti-human CD38 HIT2 FC
Go To Top Version: 2    Revision Date: 12/17/2021

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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