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PE anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
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M170_PE_042706
C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram) (gated on total cells).
  • M170_PE_042706
    C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram) (gated on total cells).
  • M170_PE_CD11b_Antibody_IHC_031413
    Fixed whole mount mouse spleen was stained with Alexa Fluor® 488 F4/80 (red) (clone BM8), Brilliant Violet 421™ CD3ε (green) (clone 145-2C11), and PE CD11b (blue) (clone M1/70). Isotype controls at the same concentrations were used for the negative control. Cells were mounted in Prolong Gold and imaged with a Leica SP8 confocal. Image courtesy of Grzegorz Chodaczek and Zbigniew Mikulski at LIAI.
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Cat # Size Price Quantity Check Availability Save
101207 50 µg $56
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101208 200 µg $173
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Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The CD11b antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
IHC - Verified
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Additional Product Notes

View more applications data for this product in our Scientific Poster Library.

Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Guo H, Cooper S, Friedman A, et al. 2017. PLoS One. 10.1371/journal.pone.0150809. PubMed
  2. Chida J, et al. 2020. PLoS Pathog. 16:e1008823. PubMed
  3. Guo Y, et al. 2021. Exp Ther Med. 353:21. PubMed
  4. Grigsby SM, et al. 2021. Cancers (Basel). 13:. PubMed
  5. Kuo PC, et al. 2021. Brain Commun. 3:fcab187. PubMed
  6. Zhao D, et al. 2021. Innate Immun. 27:533. PubMed
  7. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  8. Nigam S, et al. 2020. Mol Imaging Biol. 22:685. PubMed
  9. Yates AG, et al. 2021. J Neuroinflammation. 18:15. PubMed
  10. Witherel CE, et al. 2021. Biomaterials. 269:120667. PubMed
  11. DeBuque RJ, et al. 2022. Dev Dyn. 251:988. PubMed
  12. He D, et al. 2022. Immunity. 55:159. PubMed
  13. Koenig A, et al. 2022. Front Immunol. 12:791100. PubMed
  14. Shang SQ, et al. 2022. Neoplasma. 69:755. PubMed
  15. Tan YY, et al. 2022. Bio Protoc. 12:e4307. PubMed
  16. Wemlinger SM, et al. 2022. J Immunol. 208:1566. PubMed
  17. Li Y, et al. 2022. J Exp Clin Cancer Res. 41:128. PubMed
  18. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  19. Yue Y, et al. 2022. Nat Biomed Eng. 6:898. PubMed
  20. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  21. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  22. Albayrak E, et al. 2022. J Cell Biochem. 123:2009. PubMed
  23. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  24. Kraemer AN, et al. 2022. Front Immunol. 13:933191. PubMed
  25. McNamara NB, et al. 2023. Nature. 613:120. PubMed
  26. Sundarasivarao PYK, et al. 2022. Front Immunol. 13:1011944. PubMed
  27. Morrow RJ, et al. 2022. Cells. 11: . PubMed
  28. Ullah I, et al. 2023. Cell Rep Med. 4:100893. PubMed
  29. Pavliuchenko N, et al. 2023. Front Immunol. 13:1035226. PubMed
  30. Marritt KL, et al. 2023. Front Immunol. 13:1087991. PubMed
  31. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  32. Zhao M, et al. 2023. J Nanobiotechnology. 21:50. PubMed
  33. Wang L, et al. 2023. Oxid Med Cell Longev. 2023:6480848. PubMed
  34. Citro A, et al. 2023. Nat Commun. 14:878. PubMed
  35. Kodali S, et al. 2022. J Immunol. 208:1085. PubMed
  36. Tang Y, et al. 2022. Dev Cell. 57:480. PubMed
  37. Marsh SE, et al. 2022. Nat Neurosci. 25:306. PubMed
  38. Ajay AK, et al. 2022. Cell Rep. 38:110473. PubMed
  39. Friedman D, et al. 2022. J Immunol. 208:1845. PubMed
  40. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  41. Hu K, et al. 2022. J Extracell Vesicles. 11:e12199. PubMed
  42. Li T, et al. 2022. J Leukoc Biol. 112:845. PubMed
  43. Sauter M, et al. 2022. STAR Protoc. 3:101664. PubMed
  44. Glorieux C, et al. 2022. J Adv Res. 40:109. PubMed
  45. Krasniewski LK, et al. 2022. Elife. 11:. PubMed
  46. Wu Q, et al. 2023. Front Immunol. 13:1081719. PubMed
  47. Suzuki Y, et al. 2023. Front Immunol. 14:1089905. PubMed
  48. Zhang L, et al. 2023. Commun Biol. 6:211. PubMed
  49. Liu N, et al. 2023. Cell Death Dis. 14:170. PubMed
  50. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  51. Ma X, et al. 2023. Nat Commun. 14:1606. PubMed
  52. Mascarau R, et al. 2023. J Cell Biol. 222:. PubMed
  53. Okano F, et al. 2023. Cancer Res Commun. 3:640. PubMed
  54. He Q, et al. 2023. Parasit Vectors. 16:139. PubMed
  55. Petenkova A, et al. 2023. Nat Commun. 14:2761. PubMed
  56. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  57. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  58. Li M, et al. 2023. BMC Cancer. 23:497. PubMed
  59. Zhao C, et al. 2023. NPJ Regen Med. 8:29. PubMed
  60. Ho YH, et al. 2019. Cell Stem Cell. 25:407. PubMed
  61. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  62. Kisielow J, et al. 2019. Nat Immunol. 1.286111111. PubMed
  63. Li A, et al. 2020. Oncol Lett. 1.899305556. PubMed
  64. Lei G, et al. 2016. Antimicrob Agents Chemother. 60: 1289 - 1297. PubMed
  65. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  66. Yan F, et al. 2022. Cancer Discov. 12:792. PubMed
  67. Lee S, et al. 2021. JCI Insight. 6:. PubMed
  68. Zhao X, et al. 2022. Front Mol Biosci. 9:786864. PubMed
  69. Deng Y, et al. 2021. Acta Pharmacol Sin. 42:149. PubMed
  70. Pan J, et al. 2021. Mol Ther Nucleic Acids. 26:970. PubMed
  71. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  72. Jones NM, et al. 2019. BMC Cancer. 1.127777778. PubMed
  73. Wu N, et al. 2020. Cell Rep. 30:1129. PubMed
  74. Bhatt K, et al. 2018. mSphere. 3:e00352. PubMed
  75. Baryawno N et al. 2019. Cell. 177(7):1915-1932 . PubMed
  76. Abels ER et al. 2019. Cell Rep. 28(12):3105-3119 . PubMed
  77. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  78. Prajeeth C,et al. 2017. J Neuroinflammation.. 10.1186/s12974-017-0978-3. PubMed
  79. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  80. Zhang Y, et al. 2020. Oncol Lett. 1.053472222. PubMed
  81. Dumas SJ, et al. 2021. STAR Protocols. 2(3):100523. PubMed
  82. Zhang Z, et al. 2020. J Immunol. 204:3400. PubMed
  83. Sauter M, et al. 2022. iScience. 25:103677. PubMed
  84. Conforti A, et al. 2021. PLoS One. 16:e0259894. PubMed
  85. Götz P, et al. 2022. Int J Mol Sci. 23:. PubMed
  86. Adachi Y, et al. 2022. Nat Commun. 13:5117. PubMed
  87. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  88. Yamauchi T et al. 2018. Cancer cell. 33(3):386-400 . PubMed
  89. Xiao X, et al. 2020. J Hematol Oncol. 0.597222222. PubMed
  90. Elkabets M, et al. 2009. J Immunol. 182:4874. PubMed
  91. Forte E, et al. 2020. J Cell Mol Med. . PubMed
  92. Earnest JT, et al. 2021. Cell Reports. 35(1):108962. PubMed
  93. Jard T, et al. 2020. Cell Stem Cell. 27(4):646-662.e7. PubMed
  94. Forte D, et al. 2020. Cell Metab. 32:829. PubMed
  95. Coppo M, et al. 2016. Nat Commun. 7:12254. PubMed
  96. Wang X, et al. 2016. PLoS Pathog. 12: 1005367. PubMed
  97. Shears RK, et al. 2020. J Allergy Clin Immunol. 145:1272. PubMed
  98. Chen X, et al. 2021. Cell Death Differ. 28:1237. PubMed
  99. Stolp B, et al. 2022. Cell Rep. 38:110387. PubMed
  100. Craver BM, et al. 2020. Blood Adv. 4:312. PubMed
  101. Hiraishi Y, et al. 2018. Sci Rep. 8:18052. PubMed
  102. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  103. Llewellyn GN, et al. 2018. J Neurovirol. 24:192. PubMed
  104. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  105. Price J, et al. 2015. Diabetes. 64: 3521 - 3531. PubMed
  106. Kalucka J, et al. 2020. Cell. 764:180. PubMed
  107. Joseph R, et al. 2021. Br J Cancer. 125:176. PubMed
  108. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  109. Wang Y, et al. 2022. Acta Pharm Sin B. 12:262. PubMed
  110. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  111. Chen F, et al. 2022. Evid Based Complement Alternat Med. 2022:1240242. PubMed
  112. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  113. Turkowski K, et al. 2017. Glia. 10.1002/glia.23234. PubMed
  114. Wiese A, et al. 2017. PLoS One. 10.1371/journal.pone.0184956. PubMed
  115. Hengyou Weng et al. 2018. Cell stem cell. 22(2):191-205 . PubMed
  116. Nakagawa S et al. 2017. Cell host & microbe. 22(5):667-677 . PubMed
  117. Swidergall M, et al. 2019. Cell Rep. 28:423. PubMed
  118. Ganeshan K et al. 2019. Cell. 177(2):399-413 . PubMed
  119. LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
  120. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  121. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  122. Haugh KA, et al. 2021. eLife. 0.416666666666667. PubMed
  123. Perner C, et al. 2020. Immunity. 53(5):1063-1077.e7. PubMed
  124. Endo Y, et al. 2020. FASEB J. 34:16086. PubMed
  125. Diao N, et al. 2016. Sci Rep. 6:34672. PubMed
  126. Huang L, et al. 2016. J Biol Chem. 291: 6232 - 6244. PubMed
  127. Sharma S, et al. 2015. J Immunol. 194:5529. PubMed
  128. Li K, et al. 2022. J Immunother Cancer. 10:. PubMed
  129. Hongu T, et al. 2022. Nat Cancer. 3:486. PubMed
  130. Rogawski DS, et al. 2021. Nat Commun. 12:2792. PubMed
  131. Trenevska I, et al. 2021. PLoS One. 16:e0249967. PubMed
  132. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  133. Zhang Z, et al. 2021. Oncoimmunology. 10:1912472. PubMed
  134. Pan J, et al. 2020. J Neuroinflammation. 17:97. PubMed
  135. Paraiso HC, et al. 2018. J Neuroinflammation. 0.694444444. PubMed
  136. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  137. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  138. Hammond TR, et al. 2019. Immunity. 50:253. PubMed
  139. Wang C, et al. 2017. J Immunol. 10.4049/jimmunol.1700671. PubMed
  140. Xiao Z, et al. 2015. Cancer Lett. 360:302. PubMed
  141. Donley DW, et al. 2021. PLOS ONE. 16(5):e0250606. PubMed
  142. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  143. Ratitong B, et al. 2021. Cell Reports. 35(7):109139. PubMed
  144. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  145. Zheng Y, et al. 2022. Front Pharmacol. 12:816032. PubMed
  146. Dane EL, et al. 2022. Nat Mater. 21:710. PubMed
  147. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  148. Zhang X, et al. 2022. Cells. 11:. PubMed
  149. An J,et al. 2017. Sci Rep.. 10.1038/s41598-017-13629-0. PubMed
  150. Wang L, et al. 2017. Front Immunol.. 10.3389/fimmu.2017.01754. PubMed
  151. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  152. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  153. Zhang S, et al. 2019. Mol Med Rep. 19:5377. PubMed
  154. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  155. Riffelmacher T et al. 2017. Immunity. 47(3):466-480 . PubMed
  156. Nakaya M, et al. 2017. J Clin Invest. 127:383. PubMed
  157. Mayo L, et al. 2008. J Immunol. 181:92. PubMed
  158. Jin R, et al. 2020. Mol Cancer Ther. . PubMed
  159. Nguyen TKT, et al. 2020. Am J Pathol. 286:190. PubMed
  160. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  161. Pang D, et al. 2015. Clin Transl Immunology. 4: e41. PubMed
  162. Kotaki R, et al. 2020. Sci Rep. 10:13554. PubMed
  163. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  164. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  165. Bertino P, et al. 2019. Oncoimmunology. 8:1601482. PubMed
  166. Keshavarz M, et al. 2020. Virol J. 17:64. PubMed
  167. He L, et al. 2019. iScience. 0.790972222. PubMed
  168. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  169. Deng Z, et al. 2017. Oncogene. 36:639. PubMed
  170. Liu D et al. 2019. Immunity. 51(1):64-76 . PubMed
  171. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  172. Jaworska K, et al. 2015. J Immunol. 194:325. PubMed
  173. Chen Y, et al. 2015. PLoS One. 10: 0135217. PubMed
  174. Li L, et al. 2015. J Am Soc Nephrol. 26: 2183-2197. PubMed
  175. Souza COS, et al. 2021. iScience. 24(6):102548. PubMed
  176. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  177. Hildebrand KM, et al. 2021. PLoS One. 16:e0253864. PubMed
  178. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  179. Malekghasemi S, et al. 2020. Cell Biol Int. 44:2031. PubMed
  180. Hönes J, et al. 2017. Sci Rep. . 10.1038/s41598-017-15866-9. PubMed
  181. Niemann J, et al. 2019. Nat Commun. 10:3236. PubMed
  182. Hou M, et al. 2020. Stem Cell Res Ther. 11:55. PubMed
  183. Han D, et al. 2021. J Immunol Res. 6688053:2021. PubMed
  184. Nguyen GT, et al. 2021. iScience. 24(8):102871. PubMed
  185. Garg M, et al. 2021. Cell Reports. 34(6):108736. PubMed
  186. Cao DY, et al. 2020. J Biol Chem. 295:1369. PubMed
  187. Moorlag SJCFM, et al. 2020. Cell Rep. 33:108387. PubMed
  188. Koshida R, et al. 2015. Biochem Biophys Res Commun. 463: 109-115. PubMed
  189. Textor A, et al. 2014. Cancer Res. 74:6769. PubMed
  190. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  191. Baik JE, et al. 2022. Clin Transl Med. 12:e758. PubMed
  192. Di Martino L, et al. 2021. Cell Mol Gastroenterol Hepatol. 13:901. PubMed
  193. Zhang C, et al. 2022. Nat Commun. 13:3468. PubMed
  194. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  195. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  196. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  197. Luong-Gardiol N, et al. 2019. Cancer Cell. 35:649. PubMed
  198. Murray C, et al. 2018. Lab Chip. 18:2396. PubMed
  199. Kan X, et al. 2015. Cardiovasc Res. 10.1093/cvr/cvv255. PubMed
  200. Mizuno T, et al. 2017. Sci Rep. 7:42714. PubMed
  201. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  202. Haas MS, et al. 2020. Mol Cancer Res. 19:717. PubMed
  203. Jorapur A, et al. 2022. PLoS Pathog. 18:e1010200. PubMed
  204. Yang Y, et al. 2022. Elife. 11:. PubMed
  205. Bolkhovitina EL, et al. 2022. Int J Mol Sci. 23: . PubMed
  206. Colombo M, et al. 2022. iScience. 25:105042. PubMed
  207. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  208. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  209. He J, et al. 2019. J Clin Invest. 130. PubMed
  210. Huang Y, et al. 2019. Cancer Cell. 35:677. PubMed
  211. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  212. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  213. Liang J, et al. 2020. Sci Adv. 6:eabc3646. PubMed
  214. Koikawa K, et al. 2021. Cell. 184:4753. PubMed
  215. Sokol L, et al. 2021. STAR Protocols. 2(2):100489. PubMed
  216. Yamakawa D, et al. 2021. Cell Reports. 34(10):108817. PubMed
  217. Troutman TD, et al. 2021. STAR Protocols. 2(1):100363. PubMed
  218. Wang L, et al. 2012. PLoS One. 7:e40056. PubMed
  219. Perez-Garcia CG, et al. 2022. Mol Ther Nucleic Acids. 28:87. PubMed
  220. Uslu M, et al. 2020. J Cell Physiol. 235:9644. PubMed
  221. Zhai K, et al. 2021. Nat Cancer. 2:1136. PubMed
  222. Chiang HY, et al. 2022. Nat Commun. 13:874. PubMed
  223. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  224. Bermejo-Jambrina M, et al. 2021. EMBO J. 40:e106765. PubMed
  225. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  226. Staschke K, et al. 2009. J Immunol. 183:568. PubMed
  227. Challa TD, et al. 2020. Cell Reports. 30(10):3424-3433. PubMed
  228. Minuesa G, et al. 2019. Nat Commun. 10:2691. PubMed
  229. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  230. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  231. Wang Q, et al. 2018. Int J Biol Sci. 14:147. PubMed
  232. Langhauser F, et al. 2014. Stroke. 45:1799. PubMed
  233. Garcia-Bonilla L, et al. 2014. J Immunol. 193:2531. PubMed
  234. Favuzzi E, et al. 2021. Cell. 184(15):4048-4063.e32. PubMed
  235. Roy AG, et al. 2021. Int J Mol Sci. 22:. PubMed
  236. Liu S, et al. 2022. J Neuroinflammation. 19:35. PubMed
  237. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  238. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  239. Nuro-Gyina PK, et al. 2021. J Immunol. 207:868. PubMed
  240. Babagana M, et al. 2021. Aging (Albany NY). 13:19207. PubMed
  241. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  242. Dungan CM, et al. 2022. Aging Cell. 21:e13528. PubMed
  243. Hsu Y, et al. 2017. Biochem Biophys Res Commun.. 10.1016/j.bbrc.2017.10.067. PubMed
  244. Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed
  245. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  246. Gomez–Ospina N, et al. 2019. Nat Commun. 3.225694444. PubMed
  247. Tao Z, et al. 2019. Clin Cancer Res. 25:1113. PubMed
  248. Tan S, et al. 2006. J Immunol. 176:2872. PubMed
  249. Li T, et al. 2021. J Neuroinflammation. 81:18. PubMed
  250. Guo M, et al. 2020. Brain. 1476:143. PubMed
  251. Houben T, et al. 2020. J Pathol. 251:429. PubMed
  252. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  253. Li L, et al. 2014. J Immunol. 192:1034. PubMed
  254. Demers M, et al. 2012. Proc Natl Acad Sci U S A. 109:13076. PubMed
  255. Szeifert V, et al. 2021. Front Immunol. 12:671995. PubMed
  256. Saber M, et al. 2021. J Neurosci Res. 99:1136. PubMed
  257. Wang W, et al. 2021. J Am Heart Assoc. 10:e019142. PubMed
  258. Berghoff SA, et al. 2021. Nat Neurosci. 24:47. PubMed
  259. Cao W, et al. 2021. Int J Mol Sci. 22:. PubMed
  260. Calle P, et al. 2021. Cells. 10:. PubMed
  261. Gladow N, et al. 2020. PLoS One. 15:e0227734. PubMed
  262. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  263. Li YT, et al. 2019. Elife. 8:e47642. PubMed
  264. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  265. Xiao G, et al. 2018. Cell. 173:470. PubMed
  266. Spangenberg E, et al. 2019. Nat Commun. 10:3758. PubMed
  267. Wu ZJ, et al. 2018. Int J Oncol. 52:1209. PubMed
  268. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  269. Yuan Y, et al. 2020. Front Physiol. 0.967361111. PubMed
  270. Varikuti S, et al. 2020. Br J Cancer. 122:1005. PubMed
  271. Toyohara T, et al. 2020. Cell Stem Cell. 27:147. PubMed
  272. Dong Y, et al. 2021. Commun Biol. 4:560. PubMed
  273. Scheiblich H, et al. 2021. Cell. 184:5089. PubMed
  274. Tomimatsu M, et al. 2022. Sci Rep. 12:16656. PubMed
  275. Bennett FC, et al. 2018. Neuron. 98:1170. PubMed
  276. Zhang T, et al. 2018. PLoS One. 13:e0196571. PubMed
  277. Eisemann T, et al. 2019. Front Oncol. 9:187. PubMed
  278. Cá B, et al. 2019. Front Microbiol. 1.876388889. PubMed
  279. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  280. Lin KH, et al. 2020. Nat Genet. 52:408. PubMed
  281. Jablonski K, et al. 2015. PLoS One. 10: 0145342. PubMed
  282. Sanders K, et al. 2015. Cancer Immunol Res. 3: 891-901. PubMed
  283. Yuan C, et al. 2015. Biochem Biophys Res Commun. 464: 249-255. PubMed
  284. Resende M, et al. 2013. J Immunol. 191:262. PubMed
  285. Gerdes P, et al. 2022. Nat Commun. 13:7470. PubMed
  286. Düking T, et al. 2022. Sci Adv. 8:eabo7639. PubMed
  287. Wang X, et al. 2021. Cell. 184:5357. PubMed
  288. Li Y, et al. 2020. Theranostics. 10:2897. PubMed
  289. Xia D, et al. 2022. Mol Neurodegener. 17:41. PubMed
  290. Koide S, et al. 2022. iScience. 25:103603. PubMed
  291. Lin T, et al. 2021. PLoS Pathog. 17:e1009557. PubMed
  292. Casselli T, et al. 2021. PLoS Pathog. 17:e1009256. PubMed
  293. Muri J, et al. 2020. Cell Reports. 29(9):2731-2744.e4.. PubMed
  294. Liu Y, et al. 2019. Sci Rep. 9:18970. PubMed
  295. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  296. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  297. Li K, et al. 2020. Nat Commun. 4.844444444. PubMed
  298. Avalle L, et al. 2020. Mol Ther Methods Clin Dev. 0.793055556. PubMed
  299. Zhou Q, et al. 2020. Nat Immunol. 1.393055556. PubMed
  300. Rodríguez L, et al. 2021. Biomolecules. 11: . PubMed
  301. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  302. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  303. Zhai T, et al. 2020. Clin Exp Pharmacol Physiol. 47:677. PubMed
  304. Yang N, et al. 2022. Nat Commun. 13:2336. PubMed
  305. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  306. Schaftenaar FH, et al. 2019. Sci Rep. 9:17391. PubMed
  307. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  308. Nguyen GT, et al. 2020. eLife. 9:e56656.. PubMed
  309. Hoyer FF, et al. 2020. Immunity. 51(5):899-914.e7.. PubMed
  310. Saber M, et al. 2020. Eur J Neurosci. 52:2791. PubMed
  311. Garcia-Bonilla L, et al. 2015. J Neurosci. 35: 14783 - 14793. PubMed
  312. Baruch K, et al. 2015. EMBO J. 34: 1816 - 1828. PubMed
  313. Bozoglu T, et al. 2022. Adv Sci (Weinh). 9:e2103867. PubMed
  314. Shen H, et al. 2022. Nat Commun. 13:5013. PubMed
  315. Zhang X, et al. 2022. J Exp Clin Cancer Res. 41:246. PubMed
  316. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  317. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  318. Bahmani B, et al. 2021. Nat Commun. 12:1999. PubMed
  319. Fielding C, et al. 2022. Nat Commun. 13:543. PubMed
  320. Schmidt C, et al. 2005. J Immunol. 175:2286. PubMed
  321. Danne C et al. 2017. Cell host & microbe. 22(6):733-745 . PubMed
  322. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  323. Hirako N, et al. 2014. PLoS One. 9:103282. PubMed
  324. Chen Z, et al. 2016. Innate Immunity. 22: 419 - 432. PubMed
  325. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  326. Evavold CL, et al. 2021. Cell. 184(17):4495-4511.e19. PubMed
  327. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  328. Wang K, et al. 2021. Nat Commun. 12:4558. PubMed
  329. Henkle TR, et al. 2021. Cancer Res. 81:4560. PubMed
  330. Gawish R, et al. 2022. Elife. 11:. PubMed
  331. Wang T, et al. 2022. Int J Nanomedicine. 17:2191. PubMed
  332. Wunderlich CM, et al. 2018. Nat Commun. 9:1646. PubMed
  333. Arima Y et al. 2017. eLife. 6 pii: e25517. PubMed
  334. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  335. Zhang M, et al. 2019. Autophagy. 1.423611111. PubMed
  336. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
  337. Wong PP, et al. 2020. Cell. 181(6):1346-1363.e21. PubMed
  338. Guo S, et al. 2021. Frontiers in Immunology. 11:614667. PubMed
  339. Scharenberg SG, et al. 2020. Nat Commun. 2.76875. PubMed
  340. K K, et al. 2016. Haematologica. 151159. PubMed
  341. Han J, et al. 2015. Cancer Res . 75: 5273 - 5282. PubMed
  342. Saber M, et al. 2021. J Neurotrauma. 38:2862. PubMed
  343. Sethuraman SN, et al. 2020. Theranostics. 10:3397. PubMed
  344. Zhang SJ, et al. 2021. Adv Sci (Weinh). 8:2003410. PubMed
  345. Steinmetz TD, et al. 2021. Autophagy. 17:2238. PubMed
  346. Hohsfield LA, et al. 2021. Elife. 10:. PubMed
  347. Kaya-Tilki E, et al. 2021. PLoS One. 16:e0260633. PubMed
  348. Zhang J, et al. 2021. Stem Cell Res Ther. 12:579. PubMed
  349. Amend A, et al. 2021. Int J Mol Sci. 22:. PubMed
  350. Rana MN, et al. 2021. Front Pharmacol. 12:643215. PubMed
  351. Cai W, et al. 2019. J Neuroinflammation. 0.788194444. PubMed
  352. Fernando N, et al. 2020. Front Cell Dev Biol. 0.691666667. PubMed
  353. Dougan M, et al. 2018. Cancer Immunol Res. 6:389. PubMed
  354. Abdel Malik R, et al. 2017. Circ Res. 120:99. PubMed
RRID
AB_312790 (BioLegend Cat. No. 101207)
AB_312790 (BioLegend Cat. No. 101208)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
PE/Fire™ 744 anti-mouse/human CD11b M1/70 FC
Spark PLUS UV395™ anti-mouse/human CD11b M1/70 FC
Spark Red™ 718 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Go To Top Version: 2    Revision Date: 03/14/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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