PerCP/Fire™ 806 anti-mouse CD11c Antibody, CD11c, N418

Pricing & Availability

Clone: N418 (See other available formats)
Regulatory Status: RUO
Other Names: αX integrin, integrin αX chain, CR4, p150, ITGAX
Isotype: Armenian Hamster IgG
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Product Citations: publications

N418_PERCP-806_CD11C_Antibody_092923 — C57BL/6 splenocytes were stained with anti-mouse I-A/I-E APC and anti-mouse CD11c (clone N418) PerCP/Fire™ 806 (left) or stained with anti-mouse I-A/I-E APC only (right).

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117375

25 µg

180 CHF

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117376

100 µg

395 CHF

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Description

CD11c is a 150 kD glycoprotein also known as α_X integrin, CR4, and p150. CD11c forms a α_Xβ₂ heterodimer with β₂ integrin (CD18). It is primarily expressed on dendritic cells, NK cells, a subset of intestinal intraepithelial lymphocytes (IEL), and some activated T cells. The α_Xβ₂ integrin plays an important role in cell-cell contact by binding its ligands: iC3b, fibrinogen, and CD54.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Armenian Hamster
Immunogen: Mouse spleen dendritic cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with PerCP/Fire™ 806 under optimal conditions.
Concentration: 0.2 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

* PerCP/Fire™ 806 has a maximum excitation of 478 nm and a maximum emission of 806 nm.
Excitation Laser: Blue Laser (488 nm)
Application Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation³, immunohistochemical staining of acetone-fixed frozen sections³, immunofluorescence microscopy^{5, 9} (Alexa Fluor® 488 conjugated N418 was used for IHC in frozen sections¹⁰), and spatial biology (IBEX)^22,23.
RRID: AB_3083268 (BioLegend Cat. No. 117375)
AB_3083268 (BioLegend Cat. No. 117376)

Antigen Details

Structure: Integrin α-chain, associates with integrin β₂ (CD18), 150 kD
Distribution: Dendritic cells, NK cells, intestinal intraepithelial lymphocytes (IEL), some activated T cells
Function: Cellular adhesion
Ligand/Receptor: iC3b, fibrinogen
Cell Type: Dendritic cells, Epithelial cells, NK cells, T cells, Tregs
Biology Area: Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Barclay A, et al. 1997. The Leukocyte Antigen Facts Book Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Lopez-Rodriguez C, et al. 1996. J. Immunol. 156:3780.
Gene ID: 16411 View all products for this Gene ID
UniProt: View information about CD11c on UniProt.org

Documentation

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Related Protocols

Cell Surface Flow Cytometry Staining Protocol

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Description	Clone	Applications

Related Pages & Pathways

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Other Formats

View All CD11c Reagents Request Custom Conjugation

Description	Clone	Applications
APC anti-mouse CD11c	N418	FC
Biotin anti-mouse CD11c	N418	FC,IHC-F
FITC anti-mouse CD11c	N418	FC
PE anti-mouse CD11c	N418	FC
Purified anti-mouse CD11c	N418	FC,CyTOF®,IP,IHC
Alexa Fluor® 488 anti-mouse CD11c	N418	FC
Alexa Fluor® 647 anti-mouse CD11c	N418	FC,IHC,ICC,3D IHC
PE/Cyanine5 anti-mouse CD11c	N418	FC
PE/Cyanine7 anti-mouse CD11c	N418	FC
Brilliant Violet 605™ anti-mouse CD11c	N418	FC
Alexa Fluor® 700 anti-mouse CD11c	N418	FC
Pacific Blue™ anti-mouse CD11c	N418	FC
APC/Cyanine7 anti-mouse CD11c	N418	FC
PerCP/Cyanine5.5 anti-mouse CD11c	N418	FC
PerCP anti-mouse CD11c	N418	FC
Brilliant Violet 421™ anti-mouse CD11c	N418	FC,IHC
Brilliant Violet 570™ anti-mouse CD11c	N418	FC
Brilliant Violet 785™ anti-mouse CD11c	N418	FC
Brilliant Violet 510™ anti-mouse CD11c	N418	FC
Brilliant Violet 650™ anti-mouse CD11c	N418	FC
Purified anti-mouse CD11c (Maxpar® Ready)	N418	FC,CyTOF®
Alexa Fluor® 594 anti-mouse CD11c	N418	IHC-F,3D IHC
PE/Dazzle™ 594 anti-mouse CD11c	N418	FC
Brilliant Violet 711™ anti-mouse CD11c	N418	FC
APC/Fire™ 750 anti-mouse CD11c	N418	FC
TotalSeq™-A0106 anti-mouse CD11c	N418	PG
Brilliant Violet 750™ anti-mouse CD11c	N418	FC
TotalSeq™-B0106 anti-mouse CD11c	N418	PG
TotalSeq™-C0106 anti-mouse CD11c	N418	PG
KIRAVIA Blue 520™ anti-mouse CD11c	N418	FC
Spark Blue™ 550 anti-mouse CD11c	N418	FC
Spark NIR™ 685 anti-mouse CD11c	N418	FC
Spark UV™ 387 anti-mouse CD11c	N418	FC
Spark Red™ 718 anti-mouse CD11c	N418	FC
Spark Blue™ 515 anti-mouse CD11c	N418	FC
PerCP/Fire™ 806 anti-mouse CD11c	N418	FC
Spark PLUS UV395™ anti-mouse CD11c	N418	FC
Spark Blue™ 574 anti-mouse CD11c (Flexi-Fluor™)	N418	FC

Certificate of Analysis

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Go To Top Version: 1 Revision Date: 09.15.2023

For Research Use Only. Not for diagnostic or therapeutic use.

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