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Purified anti-human KLRG1 (MAFA) Antibody

Pricing & Availability
Clone
SA231A2 (See other available formats)
Regulatory Status
RUO
Other Names
CLEC15A, MAFA-L, MAFA-2F1, MAFA-LIKE, 2F1
Isotype
Mouse IgG2a, κ
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Product Citations
publications
SA231A2_PURE_KLRG1_Antibody_1_101916
Human peripheral blood lymphocytes were stained with CD56 Brilliant Violet 510™ and purified KLRG1 (clone SA231A2, top) or purified mouse IgG2a, κ isotype control (bottom), followed by anti-mouse IgG PE.
  • SA231A2_PURE_KLRG1_Antibody_1_101916
    Human peripheral blood lymphocytes were stained with CD56 Brilliant Violet 510™ and purified KLRG1 (clone SA231A2, top) or purified mouse IgG2a, κ isotype control (bottom), followed by anti-mouse IgG PE.
  • SA231A2_PURE_KLRG1_Antibody_2_101916
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Cat # Size Price Save
367702 100 µg ¥47,960
Description

Killer cell lectin-like receptor subfamily G member 1 (KLRG1) is a 30 kD, type II membrane glycoprotein with one C-type lectin domain and one immunoreceptor tyrosine-based inhibititory motif (ITIM). KLRG1 is expressed by subsets of NK, effector and memory T cells. KLRG1 inhibits cell activation and proliferation, and is a marker of T cell senescence. Binding of KLRG1 to E-, N-, or R- cadherins blocks phosphorylation of Akt and increases the expression of cell cycle inhibitors.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human KLRG1-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Taft J, et al. 2021. Cell. 184(17):4447-4463.e20. PubMed
  2. Wei SC et al. 2017. Cell. 170(6):1120-1133 . PubMed
  3. Kondo H, et al. 2022. Front Immunol. 13:836923. PubMed
  4. Sanz–Ortega L, et al. 2019. Front Immunol. 1.85625. PubMed
  5. Sattler A, et al. 2021. Am J Transplant. 21:87. PubMed
RRID
AB_2632728 (BioLegend Cat. No. 367702)

Antigen Details

Structure
Type II membrane glycoprotein, one C-type lectin domain, one ITIM, 30 kD.
Distribution

Subsets of NK, effector and memory T cells.

Function
Inhibits cell activation and proliferation, marker of T cell senescence.
Interaction
AKT
Ligand/Receptor
E-, N-, and R- cadherins
Cell Type
NK cells, T cells
Biology Area
Immunology, Innate Immunity
Antigen References

1. Shi L, et al. 2014. J. Immunol. 192:649.

Gene ID
10219 View all products for this Gene ID
UniProt
View information about KLRG1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 10/20/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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