- Clone
- MWReg30 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Fibrinogen receptor, gpIIb/IIIa, integrin alpha IIb, CD41a
- Isotype
- Rat IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
CD41, also known as integrin α2b and GPIIb, is a transmembrane glycoprotein that is expressed by platelets and megakaryocytes. It was reported that CD41 is also expressed on hematopoietic progenitors. CD41 associates with CD61 (integrin β3) to form complexes that interact with fibrinogen, fibronectin, von Willebrand factor, and thrombin. CD41 is required for platelet adhesion and aggregation. Defect of CD41 leads to disorders of coagulation.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse platelets
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1.0 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
CyTOF® - Verified - Recommended Usage
-
This product is suitable for use with the Maxpar® Metal Labeling Kits. For metal labeling using Maxpar® Ready antibodies, proceed directly to the step to Partially Reduce the Antibody by adding 100 µl of Maxpar® Ready antibody to 100 µl of 4 mM TCEP-R in a 50 kDa filter and continue with the protocol. Always refer to the latest version of Maxpar® User Guide when conjugating Maxpar® Ready antibodies.
- Application Notes
-
Additional reported applications (for the relevant formats) include: depletion of platelets and functional assay in vivo.4,7 The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for in vivo studies (Cat. No. 133939).
- Additional Product Notes
-
Maxpar® is a registered trademark of Standard BioTools Inc.
-
Application References
(PubMed link indicates BioLegend citation) -
- Nieswandt B, et al. 1999. Blood 94:684.
- Teeling JL, et al. 2001. Blood 98:1095.
- Bertrand JY, et al. 2005. P. Natl. Acad. Sci. USA 102:134.
- Nocito A, et al. 2007. Hepatology 45:369. (Deplete)
- Sullivan BP, et al. 2010. Toxicol. Sci. 115:286. (Deplete) PubMed
- van der Heyde HC, et al. 2005. Blood 105:1956. (FA)
- Marjon KD, et al. 2009. J. Immunol. 182:1397. (Deplete)
- Product Citations
-
- RRID
-
AB_2565433 (BioLegend Cat. No. 133919)
Antigen Details
- Structure
- A transmembrane glycoprotein that is expressed by platelets and megakaryocytes
- Distribution
-
Platelets, megakaryocytes, and hematopoietic progenitors
- Function
- Associate with CD61 (integrin β3) to form a complex which plays a major role in platelet adhesion and aggregation
- Ligand/Receptor
- Fibrinogen, fibronectin, von Willebrand factor, thrombin
- Cell Type
- Hematopoietic stem and progenitors, Megakaryocytes, Platelets
- Biology Area
- Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Bakewell SJ, et al. 2003. P. Natl. Acad. Sci. USA 100:14205.
2. Phillips DR, et al. 1991. Cell. 65:359. - Gene ID
- 16399 View all products for this Gene ID
- UniProt
- View information about CD41 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
- Can I obtain CyTOF data related to your Maxpar® Ready antibody clones?
-
We do not test our antibodies by mass cytometry or on a CyTOF machine in-house. The data displayed on our website is provided by Fluidigm®. Please contact Fluidigm® directly for additional data and further details.
- Can I use Maxpar® Ready format clones for flow cytometry staining?
-
We have not tested the Maxpar® Ready antibodies formulated in solution containing EDTA for flow cytometry staining. While it is likely that this will work in majority of the situations, it is best to use the non-EDTA formulated version of the same clone for flow cytometry testing. The presence of EDTA in some situations might negatively affect staining.
- I am having difficulty observing a signal after conjugating a metal tag to your Maxpar® antibody. Please help troubleshoot.
-
We only supply the antibody and not test that in house. Please contact Fluidigm® directly for troubleshooting advice: http://techsupport.fluidigm.com/
- Is there a difference between buffer formulations related to Maxpar® Ready and purified format antibodies?
-
The Maxpar® Ready format antibody clones are formulated in Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA. The regular purified format clones are formulated in solution that does not contain any EDTA. Both formulations are however without any extra carrier proteins.
Other Formats
View All CD41 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Brilliant Violet 421™ anti-mouse CD41 | MWReg30 | FC |
Purified anti-mouse CD41 | MWReg30 | FC,FA |
FITC anti-mouse CD41 | MWReg30 | FC |
PE anti-mouse CD41 | MWReg30 | FC |
Alexa Fluor® 488 anti-mouse CD41 | MWReg30 | FC |
APC anti-mouse CD41 | MWReg30 | FC |
PE/Cyanine7 anti-mouse CD41 | MWReg30 | FC |
PerCP/Cyanine5.5 anti-mouse CD41 | MWReg30 | FC |
Brilliant Violet 605™ anti-mouse CD41 | MWReg30 | FC |
Brilliant Violet 510™ anti-mouse CD41 | MWReg30 | FC |
Purified anti-mouse CD41 (Maxpar® Ready) | MWReg30 | FC,CyTOF® |
APC/Cyanine7 anti-mouse CD41 | MWReg30 | FC |
Alexa Fluor® 700 anti-mouse CD41 | MWReg30 | FC |
Biotin anti-mouse CD41 | MWReg30 | FC |
Pacific Blue™ anti-mouse CD41 | MWReg30 | FC |
Alexa Fluor® 647 anti-mouse CD41 | MWReg30 | FC |
PE/Dazzle™ 594 anti-mouse CD41 | MWReg30 | FC |
TotalSeq™-A0443 anti-mouse CD41 | MWReg30 | PG |
Ultra-LEAF™ Purified anti-mouse CD41 | MWReg30 | FC,FA |
TotalSeq™-B0443 anti-mouse CD41 | MWReg30 | PG |
TotalSeq™-C0443 anti-mouse CD41 | MWReg30 | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Brilliant Violet 421™ anti-mouse CD41
C57BL/6 platelets were stained with CD41 (clone MWReg30) Bri... -
Purified anti-mouse CD41
C57 BL/6 platelets were stained with CD41 (clone:MWReg30) (f... -
FITC anti-mouse CD41
C57 BL/6 platelets were stained with CD41 (clone: MWReg30) F... -
PE anti-mouse CD41
C57 BL/6 platelets were stained with CD41 (clone: MWReg30) P... -
Alexa Fluor® 488 anti-mouse CD41
C57 BL/6 platelets were stained with CD41 (clone: MWReg30) A... -
APC anti-mouse CD41
Mouse platelets were stained with either anti-mouse CD41 (cl... -
PE/Cyanine7 anti-mouse CD41
Mouse platelets were stained with anti-mouse CD41 (clone MWR... -
PerCP/Cyanine5.5 anti-mouse CD41
Mouse platelets were stained with anti-mouse CD41 (clone MWR... -
Brilliant Violet 605™ anti-mouse CD41
C57BL/6 platelets were stained with CD41 (clone MWReg30) Bri... -
Brilliant Violet 510™ anti-mouse CD41
C57BL/6 platelets were stained with CD41 (clone MWReg30) Bri... -
Purified anti-mouse CD41 (Maxpar® Ready)
Platelets isolated from mouse blood were stained with 143Nd-... -
APC/Cyanine7 anti-mouse CD41
BALB/c mouse platelets were stained with CD41 (clone MWReg30... -
Alexa Fluor® 700 anti-mouse CD41
BALB/c mouse platelets were stained with CD41 (clone MWReg30... -
Biotin anti-mouse CD41
BALB/c mouse platelets were stained with biotinylated CD41 (... -
Pacific Blue™ anti-mouse CD41
BALB/c mouse platelets were stained with CD41 (clone MWReg30... -
Alexa Fluor® 647 anti-mouse CD41
BALB/c mouse platelets were stained with CD41 (clone MWReg30... -
PE/Dazzle™ 594 anti-mouse CD41
BALB/c mouse platelets were stained with CD41 (clone MWReg30... -
TotalSeq™-A0443 anti-mouse CD41
-
Ultra-LEAF™ Purified anti-mouse CD41
C57 BL/6 platelets were stained with CD41 (clone MWReg30) (f... -
TotalSeq™-B0443 anti-mouse CD41
-
TotalSeq™-C0443 anti-mouse CD41
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