PE anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
M170_PE_042706
C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram) (gated on total cells).
  • M170_PE_042706
    C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram) (gated on total cells).
  • M170_PE_CD11b_Antibody_IHC_031413
    Fixed whole mount mouse spleen was stained with Alexa Fluor® 488 F4/80 (red) (clone BM8), Brilliant Violet 421™ CD3ε (green) (clone 145-2C11), and PE CD11b (blue) (clone M1/70). Isotype controls at the same concentrations were used for the negative control. Cells were mounted in Prolong Gold and imaged with a Leica SP8 confocal. Image courtesy of Grzegorz Chodaczek and Zbigniew Mikulski at LIAI.
Compare all formats See PE spectral data See more IHC data...
Cat # Size Price Quantity Check Availability
101207 50 µg $56.00
Check Availability


Need larger quantities of this item?
Request Bulk Quote
101208 200 µg $173.00
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Technical data sheet

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The CD11b antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
IHC - Verified
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Additional Product Notes

View more applications data for this product in our Scientific Poster Library.

Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Grigsby SM, et al. 2021. Cancers (Basel). 13:. PubMed
  2. Kuo PC, et al. 2021. Brain Commun. 3:fcab187. PubMed
  3. Zhao D, et al. 2021. Innate Immun. 27:533. PubMed
  4. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  5. Nigam S, et al. 2020. Mol Imaging Biol. 22:685. PubMed
  6. Yates AG, et al. 2021. J Neuroinflammation. 18:15. PubMed
  7. Witherel CE, et al. 2021. Biomaterials. 269:120667. PubMed
  8. DeBuque RJ, et al. 2022. Dev Dyn. 251:988. PubMed
  9. He D, et al. 2022. Immunity. 55:159. PubMed
  10. Koenig A, et al. 2022. Front Immunol. 12:791100. PubMed
  11. Shang SQ, et al. 2022. Neoplasma. 69:755. PubMed
  12. Tan YY, et al. 2022. Bio Protoc. 12:e4307. PubMed
  13. Wemlinger SM, et al. 2022. J Immunol. 208:1566. PubMed
  14. Li Y, et al. 2022. J Exp Clin Cancer Res. 41:128. PubMed
  15. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  16. Yue Y, et al. 2022. Nat Biomed Eng. 6:898. PubMed
  17. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  18. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  19. Albayrak E, et al. 2022. J Cell Biochem. 123:2009. PubMed
  20. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  21. Kraemer AN, et al. 2022. Front Immunol. 13:933191. PubMed
  22. McNamara NB, et al. 2023. Nature. 613:120. PubMed
  23. Sundarasivarao PYK, et al. 2022. Front Immunol. 13:1011944. PubMed
  24. Morrow RJ, et al. 2022. Cells. 11: . PubMed
  25. Ullah I, et al. 2023. Cell Rep Med. 4:100893. PubMed
  26. Pavliuchenko N, et al. 2023. Front Immunol. 13:1035226. PubMed
  27. Marritt KL, et al. 2023. Front Immunol. 13:1087991. PubMed
  28. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  29. Zhao M, et al. 2023. J Nanobiotechnology. 21:50. PubMed
  30. Wang L, et al. 2023. Oxid Med Cell Longev. 2023:6480848. PubMed
  31. Citro A, et al. 2023. Nat Commun. 14:878. PubMed
  32. Kodali S, et al. 2022. J Immunol. 208:1085. PubMed
  33. Tang Y, et al. 2022. Dev Cell. 57:480. PubMed
  34. Marsh SE, et al. 2022. Nat Neurosci. 25:306. PubMed
  35. Ajay AK, et al. 2022. Cell Rep. 38:110473. PubMed
  36. Friedman D, et al. 2022. J Immunol. 208:1845. PubMed
  37. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  38. Hu K, et al. 2022. J Extracell Vesicles. 11:e12199. PubMed
  39. Guo H, Cooper S, Friedman A, et al. 2017. PLoS One. 10.1371/journal.pone.0150809. PubMed
  40. Chida J, et al. 2020. PLoS Pathog. 16:e1008823. PubMed
  41. Guo Y, et al. 2021. Exp Ther Med. 353:21. PubMed
  42. Ho YH, et al. 2019. Cell Stem Cell. 25:407. PubMed
  43. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  44. Kisielow J, et al. 2019. Nat Immunol. 1.286111111. PubMed
  45. Li A, et al. 2020. Oncol Lett. 1.899305556. PubMed
  46. Li T, et al. 2022. J Leukoc Biol. 112:845. PubMed
  47. Sauter M, et al. 2022. STAR Protoc. 3:101664. PubMed
  48. Glorieux C, et al. 2022. J Adv Res. 40:109. PubMed
  49. Krasniewski LK, et al. 2022. Elife. 11:. PubMed
  50. Wu Q, et al. 2023. Front Immunol. 13:1081719. PubMed
  51. Suzuki Y, et al. 2023. Front Immunol. 14:1089905. PubMed
  52. Zhang L, et al. 2023. Commun Biol. 6:211. PubMed
  53. Liu N, et al. 2023. Cell Death Dis. 14:170. PubMed
  54. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  55. Ma X, et al. 2023. Nat Commun. 14:1606. PubMed
  56. Mascarau R, et al. 2023. J Cell Biol. 222:. PubMed
  57. Okano F, et al. 2023. Cancer Res Commun. 3:640. PubMed
  58. He Q, et al. 2023. Parasit Vectors. 16:139. PubMed
  59. Petenkova A, et al. 2023. Nat Commun. 14:2761. PubMed
  60. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  61. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  62. Li M, et al. 2023. BMC Cancer. 23:497. PubMed
  63. Zhao C, et al. 2023. NPJ Regen Med. 8:29. PubMed
  64. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  65. Yan F, et al. 2022. Cancer Discov. 12:792. PubMed
  66. Lee S, et al. 2021. JCI Insight. 6:. PubMed
  67. Zhao X, et al. 2022. Front Mol Biosci. 9:786864. PubMed
  68. Deng Y, et al. 2021. Acta Pharmacol Sin. 42:149. PubMed
  69. Pan J, et al. 2021. Mol Ther Nucleic Acids. 26:970. PubMed
  70. Lei G, et al. 2016. Antimicrob Agents Chemother. 60: 1289 - 1297. PubMed
  71. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  72. Jones NM, et al. 2019. BMC Cancer. 1.127777778. PubMed
  73. Wu N, et al. 2020. Cell Rep. 30:1129. PubMed
  74. Bhatt K, et al. 2018. mSphere. 3:e00352. PubMed
  75. Baryawno N et al. 2019. Cell. 177(7):1915-1932 . PubMed
  76. Abels ER et al. 2019. Cell Rep. 28(12):3105-3119 . PubMed
  77. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  78. Prajeeth C,et al. 2017. J Neuroinflammation.. 10.1186/s12974-017-0978-3. PubMed
  79. Sauter M, et al. 2022. iScience. 25:103677. PubMed
  80. Conforti A, et al. 2021. PLoS One. 16:e0259894. PubMed
  81. Götz P, et al. 2022. Int J Mol Sci. 23:. PubMed
  82. Adachi Y, et al. 2022. Nat Commun. 13:5117. PubMed
  83. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  84. Zhang Y, et al. 2020. Oncol Lett. 1.053472222. PubMed
  85. Dumas SJ, et al. 2021. STAR Protocols. 2(3):100523. PubMed
  86. Zhang Z, et al. 2020. J Immunol. 204:3400. PubMed
  87. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  88. Yamauchi T et al. 2018. Cancer cell. 33(3):386-400 . PubMed
  89. Xiao X, et al. 2020. J Hematol Oncol. 0.597222222. PubMed
  90. Elkabets M, et al. 2009. J Immunol. 182:4874. PubMed
  91. Shears RK, et al. 2020. J Allergy Clin Immunol. 145:1272. PubMed
  92. Chen X, et al. 2021. Cell Death Differ. 28:1237. PubMed
  93. Stolp B, et al. 2022. Cell Rep. 38:110387. PubMed
  94. Craver BM, et al. 2020. Blood Adv. 4:312. PubMed
  95. Forte E, et al. 2020. J Cell Mol Med. . PubMed
  96. Earnest JT, et al. 2021. Cell Reports. 35(1):108962. PubMed
  97. Jard T, et al. 2020. Cell Stem Cell. 27(4):646-662.e7. PubMed
  98. Forte D, et al. 2020. Cell Metab. 32:829. PubMed
  99. Coppo M, et al. 2016. Nat Commun. 7:12254. PubMed
  100. Wang X, et al. 2016. PLoS Pathog. 12: 1005367. PubMed
  101. Hiraishi Y, et al. 2018. Sci Rep. 8:18052. PubMed
  102. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  103. Llewellyn GN, et al. 2018. J Neurovirol. 24:192. PubMed
  104. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  105. Joseph R, et al. 2021. Br J Cancer. 125:176. PubMed
  106. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  107. Wang Y, et al. 2022. Acta Pharm Sin B. 12:262. PubMed
  108. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  109. Chen F, et al. 2022. Evid Based Complement Alternat Med. 2022:1240242. PubMed
  110. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  111. Price J, et al. 2015. Diabetes. 64: 3521 - 3531. PubMed
  112. Kalucka J, et al. 2020. Cell. 764:180. PubMed
  113. Turkowski K, et al. 2017. Glia. 10.1002/glia.23234. PubMed
  114. Wiese A, et al. 2017. PLoS One. 10.1371/journal.pone.0184956. PubMed
  115. Hengyou Weng et al. 2018. Cell stem cell. 22(2):191-205 . PubMed
  116. Nakagawa S et al. 2017. Cell host & microbe. 22(5):667-677 . PubMed
  117. Swidergall M, et al. 2019. Cell Rep. 28:423. PubMed
  118. Ganeshan K et al. 2019. Cell. 177(2):399-413 . PubMed
  119. LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
  120. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  121. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  122. Li K, et al. 2022. J Immunother Cancer. 10:. PubMed
  123. Hongu T, et al. 2022. Nat Cancer. 3:486. PubMed
  124. Rogawski DS, et al. 2021. Nat Commun. 12:2792. PubMed
  125. Trenevska I, et al. 2021. PLoS One. 16:e0249967. PubMed
  126. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  127. Zhang Z, et al. 2021. Oncoimmunology. 10:1912472. PubMed
  128. Haugh KA, et al. 2021. eLife. 0.416666666666667. PubMed
  129. Perner C, et al. 2020. Immunity. 53(5):1063-1077.e7. PubMed
  130. Endo Y, et al. 2020. FASEB J. 34:16086. PubMed
  131. Diao N, et al. 2016. Sci Rep. 6:34672. PubMed
  132. Huang L, et al. 2016. J Biol Chem. 291: 6232 - 6244. PubMed
  133. Sharma S, et al. 2015. J Immunol. 194:5529. PubMed
  134. Pan J, et al. 2020. J Neuroinflammation. 17:97. PubMed
  135. Paraiso HC, et al. 2018. J Neuroinflammation. 0.694444444. PubMed
  136. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  137. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  138. Hammond TR, et al. 2019. Immunity. 50:253. PubMed
  139. Wang C, et al. 2017. J Immunol. 10.4049/jimmunol.1700671. PubMed
  140. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  141. Zheng Y, et al. 2022. Front Pharmacol. 12:816032. PubMed
  142. Dane EL, et al. 2022. Nat Mater. 21:710. PubMed
  143. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  144. Zhang X, et al. 2022. Cells. 11:. PubMed
  145. Xiao Z, et al. 2015. Cancer Lett. 360:302. PubMed
  146. Donley DW, et al. 2021. PLOS ONE. 16(5):e0250606. PubMed
  147. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  148. Ratitong B, et al. 2021. Cell Reports. 35(7):109139. PubMed
  149. An J,et al. 2017. Sci Rep.. 10.1038/s41598-017-13629-0. PubMed
  150. Wang L, et al. 2017. Front Immunol.. 10.3389/fimmu.2017.01754. PubMed
  151. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  152. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  153. Zhang S, et al. 2019. Mol Med Rep. 19:5377. PubMed
  154. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  155. Riffelmacher T et al. 2017. Immunity. 47(3):466-480 . PubMed
  156. Nakaya M, et al. 2017. J Clin Invest. 127:383. PubMed
  157. Mayo L, et al. 2008. J Immunol. 181:92. PubMed
  158. Kotaki R, et al. 2020. Sci Rep. 10:13554. PubMed
  159. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  160. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  161. Jin R, et al. 2020. Mol Cancer Ther. . PubMed
  162. Nguyen TKT, et al. 2020. Am J Pathol. 286:190. PubMed
  163. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  164. Pang D, et al. 2015. Clin Transl Immunology. 4: e41. PubMed
  165. Bertino P, et al. 2019. Oncoimmunology. 8:1601482. PubMed
  166. Keshavarz M, et al. 2020. Virol J. 17:64. PubMed
  167. He L, et al. 2019. iScience. 0.790972222. PubMed
  168. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  169. Deng Z, et al. 2017. Oncogene. 36:639. PubMed
  170. Liu D et al. 2019. Immunity. 51(1):64-76 . PubMed
  171. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  172. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  173. Hildebrand KM, et al. 2021. PLoS One. 16:e0253864. PubMed
  174. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  175. Malekghasemi S, et al. 2020. Cell Biol Int. 44:2031. PubMed
  176. Jaworska K, et al. 2015. J Immunol. 194:325. PubMed
  177. Chen Y, et al. 2015. PLoS One. 10: 0135217. PubMed
  178. Li L, et al. 2015. J Am Soc Nephrol. 26: 2183-2197. PubMed
  179. Souza COS, et al. 2021. iScience. 24(6):102548. PubMed
  180. Hönes J, et al. 2017. Sci Rep. . 10.1038/s41598-017-15866-9. PubMed
  181. Niemann J, et al. 2019. Nat Commun. 10:3236. PubMed
  182. Hou M, et al. 2020. Stem Cell Res Ther. 11:55. PubMed
  183. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  184. Baik JE, et al. 2022. Clin Transl Med. 12:e758. PubMed
  185. Di Martino L, et al. 2021. Cell Mol Gastroenterol Hepatol. 13:901. PubMed
  186. Zhang C, et al. 2022. Nat Commun. 13:3468. PubMed
  187. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  188. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  189. Han D, et al. 2021. J Immunol Res. 6688053:2021. PubMed
  190. Nguyen GT, et al. 2021. iScience. 24(8):102871. PubMed
  191. Garg M, et al. 2021. Cell Reports. 34(6):108736. PubMed
  192. Cao DY, et al. 2020. J Biol Chem. 295:1369. PubMed
  193. Moorlag SJCFM, et al. 2020. Cell Rep. 33:108387. PubMed
  194. Koshida R, et al. 2015. Biochem Biophys Res Commun. 463: 109-115. PubMed
  195. Textor A, et al. 2014. Cancer Res. 74:6769. PubMed
  196. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  197. Luong-Gardiol N, et al. 2019. Cancer Cell. 35:649. PubMed
  198. Murray C, et al. 2018. Lab Chip. 18:2396. PubMed
  199. Haas MS, et al. 2020. Mol Cancer Res. 19:717. PubMed
  200. Jorapur A, et al. 2022. PLoS Pathog. 18:e1010200. PubMed
  201. Yang Y, et al. 2022. Elife. 11:. PubMed
  202. Bolkhovitina EL, et al. 2022. Int J Mol Sci. 23: . PubMed
  203. Colombo M, et al. 2022. iScience. 25:105042. PubMed
  204. Kan X, et al. 2015. Cardiovasc Res. 10.1093/cvr/cvv255. PubMed
  205. Mizuno T, et al. 2017. Sci Rep. 7:42714. PubMed
  206. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  207. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  208. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  209. He J, et al. 2019. J Clin Invest. 130. PubMed
  210. Huang Y, et al. 2019. Cancer Cell. 35:677. PubMed
  211. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  212. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  213. Liang J, et al. 2020. Sci Adv. 6:eabc3646. PubMed
  214. Perez-Garcia CG, et al. 2022. Mol Ther Nucleic Acids. 28:87. PubMed
  215. Uslu M, et al. 2020. J Cell Physiol. 235:9644. PubMed
  216. Zhai K, et al. 2021. Nat Cancer. 2:1136. PubMed
  217. Chiang HY, et al. 2022. Nat Commun. 13:874. PubMed
  218. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  219. Bermejo-Jambrina M, et al. 2021. EMBO J. 40:e106765. PubMed
  220. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  221. Koikawa K, et al. 2021. Cell. 184:4753. PubMed
  222. Sokol L, et al. 2021. STAR Protocols. 2(2):100489. PubMed
  223. Yamakawa D, et al. 2021. Cell Reports. 34(10):108817. PubMed
  224. Troutman TD, et al. 2021. STAR Protocols. 2(1):100363. PubMed
  225. Wang L, et al. 2012. PLoS One. 7:e40056. PubMed
  226. Staschke K, et al. 2009. J Immunol. 183:568. PubMed
  227. Challa TD, et al. 2020. Cell Reports. 30(10):3424-3433. PubMed
  228. Minuesa G, et al. 2019. Nat Commun. 10:2691. PubMed
  229. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  230. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  231. Wang Q, et al. 2018. Int J Biol Sci. 14:147. PubMed
  232. Roy AG, et al. 2021. Int J Mol Sci. 22:. PubMed
  233. Liu S, et al. 2022. J Neuroinflammation. 19:35. PubMed
  234. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  235. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  236. Nuro-Gyina PK, et al. 2021. J Immunol. 207:868. PubMed
  237. Babagana M, et al. 2021. Aging (Albany NY). 13:19207. PubMed
  238. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  239. Dungan CM, et al. 2022. Aging Cell. 21:e13528. PubMed
  240. Langhauser F, et al. 2014. Stroke. 45:1799. PubMed
  241. Garcia-Bonilla L, et al. 2014. J Immunol. 193:2531. PubMed
  242. Favuzzi E, et al. 2021. Cell. 184(15):4048-4063.e32. PubMed
  243. Hsu Y, et al. 2017. Biochem Biophys Res Commun.. 10.1016/j.bbrc.2017.10.067. PubMed
  244. Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed
  245. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  246. Gomez–Ospina N, et al. 2019. Nat Commun. 3.225694444. PubMed
  247. Tao Z, et al. 2019. Clin Cancer Res. 25:1113. PubMed
  248. Tan S, et al. 2006. J Immunol. 176:2872. PubMed
  249. Szeifert V, et al. 2021. Front Immunol. 12:671995. PubMed
  250. Saber M, et al. 2021. J Neurosci Res. 99:1136. PubMed
  251. Wang W, et al. 2021. J Am Heart Assoc. 10:e019142. PubMed
  252. Berghoff SA, et al. 2021. Nat Neurosci. 24:47. PubMed
  253. Cao W, et al. 2021. Int J Mol Sci. 22:. PubMed
  254. Calle P, et al. 2021. Cells. 10:. PubMed
  255. Li T, et al. 2021. J Neuroinflammation. 81:18. PubMed
  256. Guo M, et al. 2020. Brain. 1476:143. PubMed
  257. Houben T, et al. 2020. J Pathol. 251:429. PubMed
  258. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  259. Li L, et al. 2014. J Immunol. 192:1034. PubMed
  260. Demers M, et al. 2012. Proc Natl Acad Sci U S A. 109:13076. PubMed
  261. Gladow N, et al. 2020. PLoS One. 15:e0227734. PubMed
  262. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  263. Li YT, et al. 2019. Elife. 8:e47642. PubMed
  264. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  265. Xiao G, et al. 2018. Cell. 173:470. PubMed
  266. Spangenberg E, et al. 2019. Nat Commun. 10:3758. PubMed
  267. Wu ZJ, et al. 2018. Int J Oncol. 52:1209. PubMed
  268. Dong Y, et al. 2021. Commun Biol. 4:560. PubMed
  269. Scheiblich H, et al. 2021. Cell. 184:5089. PubMed
  270. Tomimatsu M, et al. 2022. Sci Rep. 12:16656. PubMed
  271. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  272. Yuan Y, et al. 2020. Front Physiol. 0.967361111. PubMed
  273. Varikuti S, et al. 2020. Br J Cancer. 122:1005. PubMed
  274. Toyohara T, et al. 2020. Cell Stem Cell. 27:147. PubMed
  275. Bennett FC, et al. 2018. Neuron. 98:1170. PubMed
  276. Zhang T, et al. 2018. PLoS One. 13:e0196571. PubMed
  277. Eisemann T, et al. 2019. Front Oncol. 9:187. PubMed
  278. Cá B, et al. 2019. Front Microbiol. 1.876388889. PubMed
  279. Gerdes P, et al. 2022. Nat Commun. 13:7470. PubMed
  280. Düking T, et al. 2022. Sci Adv. 8:eabo7639. PubMed
  281. Wang X, et al. 2021. Cell. 184:5357. PubMed
  282. Li Y, et al. 2020. Theranostics. 10:2897. PubMed
  283. Xia D, et al. 2022. Mol Neurodegener. 17:41. PubMed
  284. Koide S, et al. 2022. iScience. 25:103603. PubMed
  285. Lin T, et al. 2021. PLoS Pathog. 17:e1009557. PubMed
  286. Casselli T, et al. 2021. PLoS Pathog. 17:e1009256. PubMed
  287. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  288. Lin KH, et al. 2020. Nat Genet. 52:408. PubMed
  289. Jablonski K, et al. 2015. PLoS One. 10: 0145342. PubMed
  290. Sanders K, et al. 2015. Cancer Immunol Res. 3: 891-901. PubMed
  291. Yuan C, et al. 2015. Biochem Biophys Res Commun. 464: 249-255. PubMed
  292. Resende M, et al. 2013. J Immunol. 191:262. PubMed
  293. Muri J, et al. 2020. Cell Reports. 29(9):2731-2744.e4.. PubMed
  294. Liu Y, et al. 2019. Sci Rep. 9:18970. PubMed
  295. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  296. Rodríguez L, et al. 2021. Biomolecules. 11: . PubMed
  297. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  298. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  299. Zhai T, et al. 2020. Clin Exp Pharmacol Physiol. 47:677. PubMed
  300. Yang N, et al. 2022. Nat Commun. 13:2336. PubMed
  301. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  302. Li K, et al. 2020. Nat Commun. 4.844444444. PubMed
  303. Avalle L, et al. 2020. Mol Ther Methods Clin Dev. 0.793055556. PubMed
  304. Zhou Q, et al. 2020. Nat Immunol. 1.393055556. PubMed
  305. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  306. Schaftenaar FH, et al. 2019. Sci Rep. 9:17391. PubMed
  307. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  308. Nguyen GT, et al. 2020. eLife. 9:e56656.. PubMed
  309. Hoyer FF, et al. 2020. Immunity. 51(5):899-914.e7.. PubMed
  310. Bozoglu T, et al. 2022. Adv Sci (Weinh). 9:e2103867. PubMed
  311. Shen H, et al. 2022. Nat Commun. 13:5013. PubMed
  312. Zhang X, et al. 2022. J Exp Clin Cancer Res. 41:246. PubMed
  313. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  314. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  315. Bahmani B, et al. 2021. Nat Commun. 12:1999. PubMed
  316. Fielding C, et al. 2022. Nat Commun. 13:543. PubMed
  317. Saber M, et al. 2020. Eur J Neurosci. 52:2791. PubMed
  318. Garcia-Bonilla L, et al. 2015. J Neurosci. 35: 14783 - 14793. PubMed
  319. Baruch K, et al. 2015. EMBO J. 34: 1816 - 1828. PubMed
  320. Schmidt C, et al. 2005. J Immunol. 175:2286. PubMed
  321. Danne C et al. 2017. Cell host & microbe. 22(6):733-745 . PubMed
  322. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  323. Wang K, et al. 2021. Nat Commun. 12:4558. PubMed
  324. Henkle TR, et al. 2021. Cancer Res. 81:4560. PubMed
  325. Gawish R, et al. 2022. Elife. 11:. PubMed
  326. Wang T, et al. 2022. Int J Nanomedicine. 17:2191. PubMed
  327. Hirako N, et al. 2014. PLoS One. 9:103282. PubMed
  328. Chen Z, et al. 2016. Innate Immunity. 22: 419 - 432. PubMed
  329. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  330. Evavold CL, et al. 2021. Cell. 184(17):4495-4511.e19. PubMed
  331. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  332. Wunderlich CM, et al. 2018. Nat Commun. 9:1646. PubMed
  333. Arima Y et al. 2017. eLife. 6 pii: e25517. PubMed
  334. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  335. Zhang M, et al. 2019. Autophagy. 1.423611111. PubMed
  336. Saber M, et al. 2021. J Neurotrauma. 38:2862. PubMed
  337. Sethuraman SN, et al. 2020. Theranostics. 10:3397. PubMed
  338. Zhang SJ, et al. 2021. Adv Sci (Weinh). 8:2003410. PubMed
  339. Steinmetz TD, et al. 2021. Autophagy. 17:2238. PubMed
  340. Hohsfield LA, et al. 2021. Elife. 10:. PubMed
  341. Kaya-Tilki E, et al. 2021. PLoS One. 16:e0260633. PubMed
  342. Zhang J, et al. 2021. Stem Cell Res Ther. 12:579. PubMed
  343. Amend A, et al. 2021. Int J Mol Sci. 22:. PubMed
  344. Rana MN, et al. 2021. Front Pharmacol. 12:643215. PubMed
  345. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
  346. Wong PP, et al. 2020. Cell. 181(6):1346-1363.e21. PubMed
  347. Guo S, et al. 2021. Frontiers in Immunology. 11:614667. PubMed
  348. Scharenberg SG, et al. 2020. Nat Commun. 2.76875. PubMed
  349. K K, et al. 2016. Haematologica. 151159. PubMed
  350. Han J, et al. 2015. Cancer Res . 75: 5273 - 5282. PubMed
  351. Cai W, et al. 2019. J Neuroinflammation. 0.788194444. PubMed
  352. Fernando N, et al. 2020. Front Cell Dev Biol. 0.691666667. PubMed
  353. Dougan M, et al. 2018. Cancer Immunol Res. 6:389. PubMed
  354. Abdel Malik R, et al. 2017. Circ Res. 120:99. PubMed
RRID
AB_312790 (BioLegend Cat. No. 101207)
AB_312790 (BioLegend Cat. No. 101208)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
PE/Fire™ 744 anti-mouse/human CD11b M1/70 FC
Spark PLUS UV395™ anti-mouse/human CD11b M1/70 FC
Spark Red™ 718 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Go To Top Version: 2    Revision Date: 03/14/2013

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Login/Register
Forgot your password? Reset Password
Request an Account