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APC anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
BM8_APC_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
  • BM8_APC_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
123115 25 µg 50 CHF
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123116 100 µg 143 CHF
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Description

F4/80, also known as EMR1 or Ly71, is a 160 kD glycoprotein of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 has been widely used as a murine macrophage marker. It is expressed on a majority of tissue macrophages, including macrophages in the lung, gut, peritoneal cavity, thymus, and red pulp of the spleen, Kupffer cells, Langerhans cells, microglia, and certain dendritic cells. It is not expressed on macrophages located in the T cell areas of the spleen, lymph node, or Peyer's patch. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for the induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The F4/80 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  2. Saha D et al. 2017. Cancer cell. 32(2):253-267 . PubMed
  3. Huang W, et al. 2015. J Allergy Clin Immunol. . PubMed
  4. Barrett N, et al. 2016. Cell Rep. 16: 1039-1054. PubMed
  5. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  6. Zhao Z, et al. 2021. Nat Commun. 12:4355. PubMed
  7. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  8. Nguyen T, et al. 2021. STAR Protoc. 2:101004. PubMed
  9. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  10. Grandjean CL, et al. 2021. Sci Adv. 7:. PubMed
  11. Deng R, et al. 2022. Adv Sci (Weinh). 9:e2103343. PubMed
  12. Yang D, et al. 2022. Cell. 185:1905. PubMed
  13. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  14. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  15. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  16. Nesseler JP, et al. 2020. Cancers (Basel). 12: . PubMed
  17. Tian WJ, et al. 2021. Clin Exp Pharmacol Physiol. 48:902. PubMed
  18. Fang C, et al. 2022. J Pathol. 256:310. PubMed
  19. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  20. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  21. Yousefi M, et al. 2022. Cancer Res. 82:1589. PubMed
  22. Chen J, et al. 2022. Adv Sci (Weinh). 9:e2200668. PubMed
  23. Sipilä K, et al. 2022. Dev Cell. 57:1453. PubMed
  24. Jang HJ, et al. 2022. Cancer Res. 82:2593. PubMed
  25. Aghayev T, et al. 2022. Cancer Discov. 12:1960. PubMed
  26. Xu J, et al. 2022. Invest Ophthalmol Vis Sci. 63:15. PubMed
  27. Schaue D, et al. 2022. Antioxidants (Basel). 11: . PubMed
  28. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  29. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  30. Yoo HJ, et al. 2022. Cell Rep. 41:111598. PubMed
  31. Nagre N, et al. 2022. Respir Res. 23:326. PubMed
  32. Miao Y, et al. 2022. Front Pharmacol. 13:1032741. PubMed
  33. Kuo CS, et al. 2022. Elife. 11: . PubMed
  34. Lee DE, et al. 2022. Nat Commun. 13:7613. PubMed
  35. Wang R, et al. 2023. Nat Biomed Eng. 7:38. PubMed
  36. Yang L, et al. 2023. Acta Pharmacol Sin. :. PubMed
  37. Fan R, et al. 2023. J Immunother Cancer. 11: . PubMed
  38. Wang Y, et al. 2023. FASEB J. 37:e22776. PubMed
  39. Fontana MF, et al. 2023. Elife. 12: . PubMed
  40. Kulkarni R, et al. 2023. Life Sci Alliance. 6: . PubMed
  41. Slusarczyk P, et al. 2023. Elife. 12: . PubMed
  42. He Y, et al. 2023. Nat Commun. 14:691. PubMed
  43. Tunali G, et al. 2023. J Clin Invest. :. PubMed
  44. Li S, et al. 2023. Exp Mol Med. 55:457. PubMed
  45. Li FJ, et al. 2022. Am J Physiol Lung Cell Mol Physiol. 322:L593. PubMed
  46. Kraynak CA, et al. 2022. Int J Pharm. 618:121634. PubMed
  47. Fernández-García V, et al. 2022. Biomed Pharmacother. 148:112769. PubMed
  48. Mise Y, et al. 2022. Carcinogenesis. 43:647. PubMed
  49. Quattrocelli M, et al. 2022. J Exp Med. 219:. PubMed
  50. Hailemichael Y, et al. 2022. Cancer Cell. 40:509. PubMed
  51. Li T, et al. 2022. J Leukoc Biol. 112:845. PubMed
  52. Lin J, et al. 2022. Adv Sci (Weinh). 9:e2202633. PubMed
  53. Awida Z, et al. 2022. Int J Mol Sci. 23:. PubMed
  54. Czimmerer Z, et al. 2022. Immunity. 55:2006. PubMed
  55. Amodio V, et al. 2023. Cancer Cell. 41:196. PubMed
  56. Banerjee K, et al. 2023. Eur J Immunol. 53:e2250161. PubMed
  57. Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed
  58. Liu PS, et al. 2023. Nat Immunol. 24:452. PubMed
  59. Mizutani T, et al. 2023. iScience. 26:106081. PubMed
  60. Liu N, et al. 2023. Cell Death Dis. 14:170. PubMed
  61. Spitzer D, et al. 2023. Nat Protoc. 18:1510. PubMed
  62. Wang Y, et al. 2023. EBioMedicine. 90:104480. PubMed
  63. Tan J, et al. 2023. Acta Pharm Sin B. 13:632. PubMed
  64. Adzika GK, et al. 2023. Front Immunol. 14:1124649. PubMed
  65. Zhu S, et al. 2023. J Nanobiotechnology. 21:81. PubMed
  66. Do-Thi VA, et al. 2023. Cancer Res Commun. 3:80. PubMed
  67. He XY, et al. 2023. Nat Commun. 14:2253. PubMed
  68. Okano F, et al. 2023. Cancer Res Commun. 3:640. PubMed
  69. He Q, et al. 2023. Parasit Vectors. 16:139. PubMed
  70. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  71. Shen Z, et al. 2023. iScience. 26:106572. PubMed
  72. Ji Y, et al. 2023. Nat Cell Biol. 25:726. PubMed
  73. He Y, et al. 2023. Biomolecules. 13:. PubMed
  74. Wang C, et al. 2023. Int J Oral Sci. 15:19. PubMed
  75. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  76. Song S, et al. 2023. Bioact Mater. 28:358. PubMed
  77. Yan X, et al. 2022. Commun Biol. 5:320. PubMed
  78. Li Y, et al. 2022. Int J Biol Sci. 18:3697. PubMed
  79. He R, et al. 2021. J Immunol. 206:2353. PubMed
  80. Suresh R, et al. 2020. J Immunother Cancer. 8:. PubMed
  81. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  82. Zhang R, et al. 2021. Cell Mol Immunol. 18:1222. PubMed
  83. Kurosawa M, et al. 2021. Int J Mol Sci. 22:. PubMed
  84. He F, et al. 2021. J Exp Med. 218:. PubMed
  85. Platt DJ, et al. 2021. Cell Reports. 35(6):109113. PubMed
  86. Du J, et al. 2020. Developmental Cell. 55(6):737-753.e7. PubMed
  87. Gerwing M, et al. 2020. Mol Imaging Biol. 1.959027778. PubMed
  88. Bousset L, et al. 2020. PLoS Biol. 18:e3000948. PubMed
  89. Yu J, et al. 2020. Sci Rep. 10:21360. PubMed
  90. Sharma-Chawla N, et al. 2016. Infect Immun . . PubMed
  91. Emal D, et al. 2016. J Am Soc Nephrol. 10.1681/ASN.2016030255. PubMed
  92. Dale M, et al. 2016. J Immunol. 196: 4536 - 4543. PubMed
  93. Kawano H, et al. 2016. Int Immunol. 28: 489 - 501. PubMed
  94. Jaiswal M, et al. 2015. Sci Rep. 5: 15221. PubMed
  95. Bieren J, et al. 2015. J Immunol. 194:1154. PubMed
  96. Prantner D, et al. 2009. Infect Immun. 77:5334. PubMed
  97. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  98. Kim SE, et al. 2019. Nutrients. 11. PubMed
  99. Chang T, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006485. PubMed
  100. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  101. Yates C, et al. 2017. Stem Cell Res Ther. 10.1186/s13287-017-0644-9. PubMed
  102. Lancaster JN, et al. 2019. Nat Commun. 10:2220. PubMed
  103. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  104. Lee H, et al. 2020. Cell Metabolism. 31(4):822-836. PubMed
  105. Stubelius A, et al. 2012. Immunobiology. 217:751. PubMed
  106. Sjöstrand M, et al. 2013. J Immunol. 191:3753. PubMed
  107. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  108. Tan X, et al. 2016. PLoS One. 11: 0160985. PubMed
  109. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  110. Dong L, et al. 2021. Cancer Cell. . PubMed
  111. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  112. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  113. Sepe JJ, et al. 2022. JACC Basic Transl Sci. 7:915. PubMed
  114. Han J, et al. 2022. FEBS J. 289:417. PubMed
  115. Zhao J, et al. 2022. J Nanobiotechnology. 20:62. PubMed
  116. Liang F, et al. 2021. Front Immunol. 12:658715. PubMed
  117. Nam J, et al. 2021. Adv Sci (Weinh). 2002577:8. PubMed
  118. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  119. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  120. Xu Y, et al. 2020. Mol Ther. 28:202. PubMed
  121. Mia MM, et al. 2020. PLoS Biol. 18:e3000941. PubMed
  122. Xing J, et al. 2016. Nat Immunol. 17:1373-1380. PubMed
  123. Zhu J, et al. 2016. Sci Rep. 6:27136. PubMed
  124. Sun P, et al. 2015. J Hepatol. . PubMed
  125. Shen H, et al. 2015. Infect Immun . 83: 2694 - 2704. PubMed
  126. Gritsina G, et al. 2015. Mol Cancer Ther. 14:1035. PubMed
  127. Wong E, et al. 2019. Cell Rep. 29:3047. PubMed
  128. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  129. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  130. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  131. Qi F, et al. 2017. Molecular Immunology. 10.1016/j.molimm.2017.05.008. PubMed
  132. Stefan K, et al. 2017. PLoS One. . 10.1371/journal.pone.0188600. PubMed
  133. Sinha M, et al. 2018. Nat Commun. 9:936. PubMed
  134. Grohmann M et al. 2018. Cell. 175(5):1289-1306 . PubMed
  135. Kosack L, et al. 2017. Sci Rep. 7:11289. PubMed
  136. Christopher S Garris et al. 2018. Immunity. 49(6):1148-1161 . PubMed
  137. Duarte N, et al. 2018. Hepatol Commun. 0.833333333. PubMed
  138. Zhong J, et al. 2018. Sci Adv. 4:eaas9864. PubMed
  139. Rybalko V, et al. 2015. PLoS One. 10: 0145550. PubMed
  140. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  141. Tajfirouz D, et al. 2017. Virology. 10.1016/j.virol.2017.02.022. PubMed
  142. Krivanek J, et al. 2020. Nat Commun. 3.802777778. PubMed
  143. Brestoff JR, et al. 2021. Cell Metab. 33:270. PubMed
  144. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  145. Esmaili S, et al. 2021. Cell Systems. 12(5):432-445.e7. PubMed
  146. Jeong D, et al. 2021. eLife. 0.416666666666667. PubMed
  147. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  148. Sun Q, et al. 2022. Cell Death Dis. 13:724. PubMed
  149. Wang Y, et al. 2022. Front Immunol. 13:767630. PubMed
  150. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  151. Kosaric N, et al. 2020. Mol Ther. 28:2007. PubMed
  152. Ling X, et al. 2021. ACS Nano. 15:765. PubMed
  153. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  154. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  155. Jiao H, et al. 2021. Cell. 184(11):2896-2910.e13. PubMed
  156. Shang Y, et al. 2016. Nat Immunol. 10.1038/ni.3486. PubMed
  157. Lasky C, et al. 2015. Infect Immun . 83: 2627 - 2635. PubMed
  158. Peng L, et al. 2020. Transl Lung Cancer Res. 0.892361111. PubMed
  159. Vannini N, et al. 2019. Cell Stem Cell. 24:405. PubMed
  160. Nguyen CM, et al. 2019. Diabetes. 68:1499. PubMed
  161. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  162. Cao W, et al. 2017. Immunity. 47:1182. PubMed
  163. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  164. Luan HH et al. 2019. Cell. 178(5):1231-1244 . PubMed
  165. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  166. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  167. Galvão I, et al. 2018. Front Immunol. 9:142. PubMed
  168. Alexander RK, et al. 2020. eLife. 9:e54090.. PubMed
  169. Prantner D, et al. 2011. Infect Immun. 79:3922. PubMed
  170. Helmi N, et al. 2015. J Infect Dis. 211:1677. PubMed
  171. Tsoyi K, et al. 2015. J Leukoc Biol. 97:171. PubMed
  172. Ma Y, et al. 2015. Cardiovasc Res. 106:421. PubMed
  173. Ben-Shaanan T, et al. 2016. Nat Med. 10.1038/nm.4133. PubMed
  174. Karki R, et al. 2020. JCI Insight. 5:00. PubMed
  175. Chi Z, et al. 2020. Molecular Cell. 80(1):43-58.e7. PubMed
  176. Sun L, et al. 2020. J Immunol. 2177:204. PubMed
  177. Müller A, et al. 2020. J Clin Invest. 5765:130. PubMed
  178. Jeong SJ, et al. 2021. Autophagy. 17:3740. PubMed
  179. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  180. Shin JE, et al. 2021. Heliyon. 7:e08433. PubMed
  181. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  182. Zein HS, et al. 2022. Sci Rep. 12:4834. PubMed
  183. Luo W, et al. 2022. Front Immunol. 13:816761. PubMed
  184. Lv F, et al. 2022. iScience. 25:103639. PubMed
  185. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  186. Stump CT, et al. 2021. Open Biol. 11:210245. PubMed
  187. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  188. Gao H, et al. 2021. Cells. 10:. PubMed
  189. Carozza JA, et al. 2020. Nat Cancer. 184:1. PubMed
  190. Agrawal V, et al. 2016. J Leukoc Biol. 100: 261 - 274. PubMed
  191. Amash A, et al. 2016. J Immunol. 196: 3331-3340. PubMed
  192. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  193. Sullivan B, et al. 2015. PLoS Pathog. 11:1004588. PubMed
  194. Oatley J, et al. 2009. Development. 136:1191. PubMed
  195. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  196. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  197. Yu Y, et al. 2019. J Clin Invest. 129:546. PubMed
  198. Linde N, et al. 2018. Nat Commun. 9:21. PubMed
  199. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  200. Chen F et al. 2018. Cell reports. 25(10):2775-2783 . PubMed
  201. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  202. Deng M, et al. 2020. Nat Commun. 11:2193. PubMed
  203. Glauser D, et al. 2013. J Virol. 87:10828. PubMed
  204. Bretscher P, et al. 2015. EMBO Mol Med. 7:593. PubMed
  205. Hara-Chikuma H 2016. Mol Cell Biol. 36: 1206-1218. PubMed
  206. Hu J, et al. 2020. Theranostics. 7.154166667. PubMed
  207. DeVito NC, et al. 2021. Cell Reports. 35(5):109071. PubMed
  208. Gozgit JM, et al. 2021. Cancer Cell. :. PubMed
  209. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  210. Shi R, et al. 2022. Theranostics. 12:875. PubMed
  211. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  212. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  213. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  214. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  215. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  216. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  217. Tartey S, et al. 2021. Cancer Research. 81(9):2358-2372. PubMed
  218. Cheng Y, et al. 2020. PLoS Pathog. 16:e1008569. PubMed
  219. Wang W, et al. 2018. Oncogenesis. 7:97. PubMed
  220. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  221. Wang T, et al. 2018. Front Physiol. 9:209. PubMed
  222. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  223. Moon HG et al. 2018. Immunity. 49(2):275-287 . PubMed
  224. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  225. Hu J, et al. 2019. Mol Ther Nucleic Acids. 16:650. PubMed
  226. Matundan H, et al. 2019. J Virol. 93. PubMed
  227. Yu L, et al. 2019. Elife. 8:e46677. PubMed
  228. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  229. Li Y, et al. 2020. Cell Reports. 27(10):2809-2816.e3.. PubMed
  230. Fairfax K, et al. 2013. J Immunol. 191:4202. PubMed
  231. Ericson J, et al. 2014. PLoS One. 9:108553. PubMed
  232. Toda G, et al. 2021. STAR Protoc. 2:100246. PubMed
  233. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  234. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  235. Fraccarollo D, et al. 2021. eLife. 0.416666666666667. PubMed
  236. Pfefferlé M, et al. 2021. Front Immunol. 12:680855. PubMed
  237. Wara AK, et al. 2020. Cell Rep. 33:108550. PubMed
  238. Fu Z, et al. 2021. Cell Res. 31:631. PubMed
  239. Yang Y, et al. 2022. Elife. 11:. PubMed
  240. Chung EJ, et al. 2022. Aging (Albany NY). 14:7692. PubMed
  241. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  242. Lang V, et al. 2021. Elife. 10:. PubMed
  243. Jaggi U, et al. 2021. PLoS Pathog. 17:e1009999. PubMed
  244. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  245. Tapia-Abellán A, et al. 2021. Sci Adv. 7:eabf4468. PubMed
  246. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  247. Frenis K, et al. 2021. Basic Res Cardiol. 31:116. PubMed
  248. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  249. Dewi IMW, et al. 2021. Cell Reports Medicine. 2(5):100289. PubMed
  250. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  251. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  252. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  253. Kostadinova E, et al. 2016. Sci Rep. 6:30943. PubMed
  254. Tan X, et al. 2015. Sci Rep. 5: 15702. PubMed
  255. Kuwahara G, et al. 2014. PLoS One. 9:106987. PubMed
  256. Patankar Y, et al. 2013. Infect Immun . 81:2043. PubMed
  257. Kyburz A, et al. 2019. J Allergy Clin Immunol. 143:1496. PubMed
  258. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  259. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  260. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  261. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  262. Brown SM et al. 2017. Endocrinology. 158(10):3592-3604 . PubMed
  263. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  264. Zheng X, et al. 2018. J Clin Invest. 128:2104. PubMed
  265. Cao Q, et al. 2019. Theranostics. 5.576388889. PubMed
  266. Kim K, et al. 2014. Proc Natl Acad Sci U S A. 111:11774. PubMed
  267. Hu J, et al. 2015. J Hepatol. Available online 31 August 2015. PubMed
  268. Terrazas M 2014. Int J Parasit. 44 613 . PubMed
  269. Yang C, et al. 2016. Sci Rep. 6:34643. PubMed
  270. Jiang Q, et al. 2020. JCI Insight. 5:00. PubMed
  271. Kesavardhana S, et al. 2020. J Biol Chem. 295:8325. PubMed
  272. Ye ZH, et al. 2021. Transl Oncol. 14:101162. PubMed
  273. Ito T, et al. 2021. Nat Commun. 12:2232. PubMed
  274. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  275. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  276. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  277. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  278. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  279. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  280. Li D, et al. 2022. Emerg Microbes Infect. 11:2248. PubMed
  281. Pascual-Pasto G, et al. 2022. J Immunother Cancer. 10:. PubMed
  282. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  283. Zhou J, et al. 2022. Int J Oncol. 61: . PubMed
  284. Chen F, et al. 2022. Cell Rep. 38:110215. PubMed
  285. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  286. Bent EH, et al. 2021. Nat Commun. 12:6218. PubMed
  287. Calle P, et al. 2021. Cells. 10:. PubMed
  288. Ishikura S, et al. 2021. J Cell Biochem. . PubMed
  289. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  290. Desai P, et al. 2021. Cell. 184(5):1214-1231.e16. PubMed
  291. Chen Z, et al. 2016. Nat Commun. 7:11596. PubMed
  292. Deng W, et al. 2015. Clin Immunol. . PubMed
  293. Honda H, et al. 2014. J Leukoc Biol. 96:1087. PubMed
  294. Shaw O, et al. 2014. Rheumatology. 53:1901. PubMed
  295. Rosenbaum SR, et al. 2020. Cell Rep. 30:510. PubMed
  296. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  297. Petkevicius K, et al. 2019. Elife. 8:e47990. PubMed
  298. Cianciaruso C, et al. 2020. Cell Reports. 27(10):3062-3080.e11.. PubMed
  299. Engblom C, et al. 2017. Science. 358:6367. PubMed
  300. Zhao F et al. 2018. Immunity. 48(1):147-160 . PubMed
  301. Lima-Junior D, et al. 2017. J Immunol. 10.4049/jimmunol.1700258. PubMed
  302. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  303. Horsle B 2013. Development. 140:1517. PubMed
  304. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  305. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  306. Gamradt P, et al. 2016. PLoS Pathog. 12:e1006032. PubMed
  307. Wang X, et al. 2016. J Immunol. 197(12):4750-4761. PubMed
  308. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  309. Tian Y, et al. 2020. JCI Insight. 5:00. PubMed
  310. Kerkhofs D, et al. 2020. Theranostics. 7.022222222. PubMed
  311. Toda G, et al. 2020. Molecular Cell. 79(1):43-53.e4. PubMed
  312. Karki R, et al. 2020. bioRxiv. . PubMed
  313. Hua X, et al. 2021. Front Immunol. 12:706027. PubMed
  314. Liu J, et al. 2021. Front Immunol. 12:733808. PubMed
  315. Feng L, et al. 2022. Signal Transduct Target Ther. 7:21. PubMed
  316. Zhang MS, et al. 2022. Nat Commun. 13:954. PubMed
  317. Pan Y, et al. 2021. Br J Pharmacol. 178:4907. PubMed
  318. Zhu K, et al. 2022. EMBO Rep. 23:e54499. PubMed
  319. Ding R, et al. 2022. J Neuroinflammation. 19:137. PubMed
  320. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  321. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  322. Panagi M, et al. 2020. Theranostics. 10:1910. PubMed
  323. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  324. Gu H, et al. 2021. Elife. 10:. PubMed
  325. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  326. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  327. Li K, et al. 2020. J Cell Mol Med. 24:13115. PubMed
  328. Karki R, et al. 2021. Cell. 184:149. PubMed
  329. Caoa X, et al. 2017. Neurosci Lett. 10.1016/j.neulet.2017.02.045. PubMed
  330. Jeurissen M, et al. 2016. PLoS One. 11:e0167199. PubMed
  331. Montero-Barrera D, et al. 2015. BioMed Res Int. 2015 615865. PubMed
  332. Neimert-Andersson T, et al. 2011. Vaccine. 29:8965. PubMed
  333. Sun L, et al. 2009. FASEB J. 3.602777778. PubMed
  334. Esposito E, et al. 2019. Nat Commun. 4.101388889. PubMed
  335. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  336. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  337. Nishino T, et al. 2018. Arterioscler Thromb Vasc Biol. 38:2460. PubMed
  338. Meng Michelle Xu et al. 2017. Immunity. 47(2):363-373 . PubMed
  339. Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed
  340. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  341. Chan JY, et al. 2019. Diabetologia. 62:993. PubMed
  342. Mirsoian A, et al. 2014. J Exp Med. 211:2373. PubMed
  343. Yin X, et al. 2015. J Immunol. 194:4029. PubMed
  344. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  345. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  346. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  347. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  348. Adzika GK, et al. 2021. Front Cell Dev Biol. 9:719351. PubMed
  349. Ling X, et al. 2021. Biomaterials. 270:120690. PubMed
  350. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  351. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  352. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  353. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  354. Adzika GK, et al. 2021. Front Cardiovasc Med. 8:719805. PubMed
  355. Wang X, et al. 2021. Theranostics. 11:209. PubMed
  356. Liu SS, et al. 2021. Immunity. :. PubMed
  357. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
  358. Cao H, et al. 2020. Front Pharmacol. 11:578943. PubMed
  359. Ngkelo A, et al. 2016. J Exp Med. 213: 1353 - 1374. PubMed
  360. Sockolosky J, et al. 2016. Proc Natl Acad Sci U S A. 113: 2646 - 2654. PubMed
  361. Wan X, Thomas J, Unanue E 2016. J Exp Med. 213: 967 - 978. PubMed
  362. Ishizuka M, et al. 2015. PLoS One. 10: 0137978. PubMed
  363. Pechous R, et al. 2015. MBio. 6:2302. PubMed
  364. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  365. Klezovich-Bénard M, et al. 2012. PLoS One. 8:e1002481. PubMed
  366. Karpurapu M, et al. 2011. Blood. 118:5255. PubMed
  367. Yan K, et al. 2020. Cell Death Dis. 1.013888889. PubMed
  368. Eghbalzadeh K, et al. 2019. Front Immunol. 2.022916667. PubMed
  369. Ouadah Y, et al. 2019. Cell. 179:403. PubMed
  370. Saul S, et al. 2019. J Leukoc Biol. N/A. PubMed
  371. Koupenova M, et al. 2019. iScience. 19:916. PubMed
  372. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  373. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  374. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  375. Kim M, et al. 2012. J Immunol. 188:4158. PubMed
  376. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  377. Bramwell K, et al. 2015. J Immunol. 195: 1647 - 1656. PubMed
  378. Legrain S, et al. 2015. J Immunol. 195: 4171 - 4175. PubMed
  379. Schuijs M, et al. 2016. PLoS One. 11: 016188. PubMed
  380. Lerbs T, et al. 2020. JCI Insight. 5:00. PubMed
  381. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  382. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  383. Fu W, et al. 2020. J Immunol Res. 8820355:2020. PubMed
  384. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  385. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  386. Caporarello N, et al. 2022. Nat Commun. 13:4170. PubMed
  387. Fearon AE, et al. 2021. iScience. 24:103143. PubMed
  388. Chung EJ, et al. 2021. Int J Radiat Oncol Biol Phys. 110:526. PubMed
  389. Murray CW, et al. 2022. Nat Commun. 13:1090. PubMed
  390. Qu J, et al. 2021. Int J Biol Sci. 17:2756. PubMed
  391. Liu ZZ, et al. 2021. Front Immunol. 12:636861. PubMed
  392. Zhang B, et al. 2021. Front Neurol. 607370:12. PubMed
  393. Kapralov AA, et al. 2020. Nat Chem Biol. 278:16. PubMed
  394. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  395. Badgujar DC, et al. 2020. PLoS Pathog. 16:e1009016. PubMed
  396. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
  397. Malik M, et al. 2012. Proc Natl Acad Sci U S A. 109:6130. PubMed
  398. Kim SH, et al. 2020. Neoplasia. 1.3375. PubMed
  399. Maas SLN, et al. 2020. J Neuroinflammation. 17:120. PubMed
  400. Thomson CA, et al. 2018. J Immunol. 201:215. PubMed
  401. Sparber F et al. 2019. British journal of pharmacology. 176(11):1728-1744 . PubMed
  402. Lalor R, et al. 2019. Nutrients. 11. PubMed
RRID
AB_893481 (BioLegend Cat. No. 123115)
AB_893481 (BioLegend Cat. No. 123116)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kupffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
UniProt
View information about F4/80 on UniProt.org

Other Formats

View All F4/80 Reagents Request Custom Conjugation
Description Clone Applications
Brilliant Violet 605™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 BM8 FC,IHC,WB
Biotin anti-mouse F4/80 BM8 FC,IHC
FITC anti-mouse F4/80 BM8 FC
PE anti-mouse F4/80 BM8 FC
PE/Cyanine5 anti-mouse F4/80 BM8 FC
PE/Cyanine7 anti-mouse F4/80 BM8 FC
APC anti-mouse F4/80 BM8 FC
APC/Cyanine7 anti-mouse F4/80 BM8 FC
Alexa Fluor® 488 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Alexa Fluor® 647 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Pacific Blue™ anti-mouse F4/80 BM8 FC
PerCP anti-mouse F4/80 BM8 FC
PerCP/Cyanine5.5 anti-mouse F4/80 BM8 FC
Alexa Fluor® 700 anti-mouse F4/80 BM8 FC
Brilliant Violet 421™ anti-mouse F4/80 BM8 FC,IHC-F,SB
Brilliant Violet 510™ anti-mouse F4/80 BM8 FC
Alexa Fluor® 594 anti-mouse F4/80 BM8 IHC-F
Brilliant Violet 785™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 (Maxpar® Ready) BM8 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse F4/80 BM8 FC
Brilliant Violet 650™ anti-mouse F4/80 BM8 FC
Brilliant Violet 711™ anti-mouse F4/80 BM8 FC
APC/Fire™ 750 anti-mouse F4/80 BM8 FC
TotalSeq™-A0114 anti-mouse F4/80 BM8 PG
TotalSeq™-B0114 anti-mouse F4/80 BM8 PG
TotalSeq™-C0114 anti-mouse F4/80 BM8 PG
Spark YG™ 570 anti-mouse F4/80 BM8 IHC-F
KIRAVIA Blue 520™ anti-mouse F4/80 BM8 FC
Ultra-LEAF™ Purified anti-mouse F4/80 BM8 FC,IHC,WB
APC/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark NIR™ 685 anti-mouse F4/80 BM8 FC
Spark Blue™ 550 anti-mouse F4/80 BM8 FC
Brilliant Violet 570™ anti-mouse F4/80 BM8 FC
Brilliant Violet 750™ anti-mouse F4/80 BM8 FC
PE/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark Red™ 718 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Spark Blue™ 574 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Go To Top Version: 2    Revision Date: 10.25.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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