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Purified anti-human CD142 Antibody

Pricing & Availability
Clone
NY2 (See other available formats)
Regulatory Status
RUO
Other Names
Coagulation Factor III, Tissue Factor (TF), Thromboplastin, platelet tissue factor, factor III, factor 3, F3, F-3, TFA
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
NY2_PURE_CD142_Antibody_FC_121014
LPS-stimulated human monocytes were stained with purified CD142 (clone NY2) (filled histogram), or purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG FITC.
  • NY2_PURE_CD142_Antibody_FC_121014
    LPS-stimulated human monocytes were stained with purified CD142 (clone NY2) (filled histogram), or purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG FITC.
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365202 100 µg 136 CHF
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Description

CD142, also known as Tissue Factor (TF), Coagulation Factor III, and Thromboplastin, is a 45 kD type I transmembrane glycoprotein. It is expressed on the surface of a variety of cells that are physically separated from the circulating blood which include smooth muscle cells, fibroblasts, keratinocytes, glomerular epithelial cells (cytoplasmic inclusions), astrocytes, myocardium, liver stromal cells, pancreas cells, and is also expressed on activated monocytes and stimulated endothelial cells. CD142 is a high-affinity receptor for coagulation factor VII and initiates the extrinsic pathway of blood coagulation. CD142 also plays an important role in a variety of diseases such as sepsis, atherosclerosis, and cancer.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. NULL, et al. 2022. Cell. 185:916. PubMed
RRID
AB_2564564 (BioLegend Cat. No. 365202)

Antigen Details

Structure
45 kD Type I transmembrane glycoprotein.
Distribution

Smooth muscle cells, fibroblasts, keratinocytes, glomerular epithelial cells, astrocytes, myocardium, liver stromal cells, pancreas cell, stimulated endothelial cells, stimulated monocytes

Function
Blood coagulation
Ligand/Receptor
Coagulation Factor VII
Cell Type
Astrocytes, Endothelial cells, Epithelial cells, Fibroblasts
Biology Area
Angiogenesis, Cell Biology, Immunology
Molecular Family
CD Molecules
Antigen References

1. Carson SD, et al. 1994. Blood 84:526.
2. McComb RD, et al. 1991. Am. J. Pathol. 139:491.
3. Whittle SM, et al. 1995. Thromb. Res. 79:451.

Gene ID
2152 View all products for this Gene ID
UniProt
View information about CD142 on UniProt.org
Go To Top Version: 1    Revision Date: 12.16.2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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