Loading...

APC anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
M1slash70_APC_042706
C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) APC (filled histogram) or rat IgG2b, κ APC isotype control (open histogram) (gated on total cells).
  • M1slash70_APC_042706
    C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) APC (filled histogram) or rat IgG2b, κ APC isotype control (open histogram) (gated on total cells).
Compare all formats See APC spectral data
Cat # Size Price Save
101211 25 µg ¥7,260
101212 100 µg ¥21,850
Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The CD11b antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Chuang H, et al. 2014. Nat Commun. 5:4602. PubMed
  2. Guo H, Cooper S, Friedman A, et al. 2017. PLoS One. 10.1371/journal.pone.0150809. PubMed
  3. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  4. Chen Q, et al. 2019. Cell Stem Cell. 25(6):768-783.e6. PubMed
  5. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  6. Frieler RA, et al. 2017. Exp Neurol. 298:104. PubMed
  7. Combes F, et al. 2018. Neoplasia. 20:848. PubMed
  8. Lin C et al. 2019. Immunity. 50(1):137-151 . PubMed
  9. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  10. Jiang W, et al. 2017. Sci Rep. 7:6501. PubMed
  11. Schröder N, et al. 2020. J Neuroinflammation. 17:131. PubMed
  12. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  13. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  14. Kuo PC, et al. 2021. Brain Commun. 3:fcab187. PubMed
  15. Li F, et al. 2022. Mediators Inflamm. 2022:5782922. PubMed
  16. Hao Y, et al. 2022. Exp Ther Med. 23:350. PubMed
  17. Yang D, et al. 2022. Cell. 185:1905. PubMed
  18. Kataru RP, et al. 2021. Sci Signal. 14:. PubMed
  19. Bruno MEC, et al. 2022. J Cell Physiol. 237:706. PubMed
  20. Friesen M, et al. 2022. Brain Pathol. 32:e13032. PubMed
  21. Zhang C, et al. 2022. Genomics Proteomics Bioinformatics. :. PubMed
  22. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  23. Gadipudi LL, et al. 2022. Clin Sci (Lond). 136:643. PubMed
  24. Guttman O, et al. 2022. J Cell Biol. 221: . PubMed
  25. Van Deren DA, et al. 2022. Development. 149: . PubMed
  26. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  27. Liu X, et al. 2022. Adv Sci (Weinh). 9:e2105650. PubMed
  28. Tsumita T, et al. 2022. Int J Cancer. 151:944. PubMed
  29. Li F, et al. 2022. Gut Microbes. 14:2096989. PubMed
  30. Liu X, et al. 2022. Chin Med J (Engl). 135:1821. PubMed
  31. Li X, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:1077. PubMed
  32. Wu X, et al. 2022. J Clin Med. 11: . PubMed
  33. Zhang Z, et al. 2022. Mol Nutr Food Res. 66:e2200300. PubMed
  34. Li GX, et al. 2022. Int J Biochem Cell Biol. 152:106299. PubMed
  35. Wohlgemuth L, et al. 2022. Cells. 11: . PubMed
  36. Millar FR, et al. 2022. Cell Rep. 41:111596. PubMed
  37. Liu M, et al. 2022. Cells. 11: . PubMed
  38. Zhu J, et al. 2022. Nat Commun. 13:7466. PubMed
  39. Cai S, et al. 2023. J Clin Invest. 133: . PubMed
  40. Lee DE, et al. 2022. Nat Commun. 13:7613. PubMed
  41. Cheng P, et al. 2023. Pharmacol Res. 188:106643. PubMed
  42. Domingos-Pereira S, et al. 2022. Int J Mol Sci. 24: . PubMed
  43. Cagle LA, et al. 2023. Front Physiol. 13:1059686. PubMed
  44. Jin SM, et al. 2023. Nat Nanotechnol. :. PubMed
  45. Zhang L, et al. 2023. J Inflamm Res. 16:109. PubMed
  46. Olivares-González L, et al. 2022. Antioxidants (Basel). 12: . PubMed
  47. Peng Y, et al. 2023. Respir Res. 24:33. PubMed
  48. Wang C, et al. 2023. Exp Mol Med. 55:347. PubMed
  49. Schwartz M, et al. 2023. Nat Microbiol. 8:455. PubMed
  50. Tsioti I, et al. 2023. J Neuroinflammation. 20:25. PubMed
  51. Hattori Y, et al. 2023. Cell Rep. 42:112092. PubMed
  52. Chen Y, et al. 2023. Stem Cells Int. 2023:7482546. PubMed
  53. Lu QK, et al. 2022. Acta Pharmacol Sin. 43:376. PubMed
  54. Liu X, et al. 2022. Pain. 163:508. PubMed
  55. Ryan CB, et al. 2022. Neurobiol Dis. 163:105608. PubMed
  56. Sohn J, et al. 2022. Blood Adv. 6:2557. PubMed
  57. Howard ZM, et al. 2022. Am J Physiol Cell Physiol. 322:C354. PubMed
  58. Ma Y, et al. 2022. Am J Physiol Heart Circ Physiol. 322:H622. PubMed
  59. Leick MB, et al. 2022. Cancer Cell. 40:494. PubMed
  60. Pulous FE, et al. 2022. Nat Neurosci. 25:567. PubMed
  61. Pfeifhofer-Obermair C, et al. 2022. Bio Protoc. 12:e4378. PubMed
  62. Bruggemann TR, et al. 2022. iScience. 25:105185. PubMed
  63. Awida Z, et al. 2022. Int J Mol Sci. 23:. PubMed
  64. Abdel-Haq R, et al. 2022. Elife. 11:. PubMed
  65. Zhang Y, et al. 2023. Invest Ophthalmol Vis Sci. 64:1. PubMed
  66. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  67. Zhang X, et al. 2023. Heliyon. 9:e13490. PubMed
  68. Zhong WJ, et al. 2023. J Transl Med. 21:179. PubMed
  69. Ma X, et al. 2023. Nat Commun. 14:1606. PubMed
  70. Zhuang WR, et al. 2023. Nat Commun. 14:1675. PubMed
  71. Rundberg Nilsson A, et al. 2023. iScience. 26:106341. PubMed
  72. Palakurthi B, et al. 2023. Nat Commun. 14:2109. PubMed
  73. Silva BM, et al. 2023. J Clin Invest. 133:. PubMed
  74. Duan JL, et al. 2023. Nat Aging. 3:258. PubMed
  75. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  76. Yu PC, et al. 2023. Pharmaceuticals (Basel). 16:. PubMed
  77. Arora S, et al. 2023. PLoS One. 18:e0286211. PubMed
  78. Kase N, et al. 2023. Front Cell Dev Biol. 11:1022081. PubMed
  79. Tsugawa H, et al. 2023. PLoS Pathog. 19:e1011139. PubMed
  80. Fixsen BR, et al. 2023. Nat Immunol. . PubMed
  81. Almada AE, et al. 2021. Cell Reports. 34(4):108656. PubMed
  82. Kokona D, et al. 2016. Exp Eye Res. S0014-4835(16)30499-7. PubMed
  83. Oliveira-Lima OC, et al. 2015. Immunobiology. . PubMed
  84. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  85. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  86. Page N, et al. 2018. Immunity. 48:937. PubMed
  87. Frisbee AL, et al. 2019. Nat Commun. 10:2712. PubMed
  88. Sanders KA, et al. 2019. Sci Rep. 9:231. PubMed
  89. Hirata Y et al. 2018. Cell stem cell. 22(3):445-453 . PubMed
  90. Wang F, et al. 2018. Oncogenesis. 7:41. PubMed
  91. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  92. Tripathi H, et al. 2020. J Mol Cell Cardiol. 149:95. PubMed
  93. d'Errico P, et al. 2021. Nat Neurosci. Online ahead of print. PubMed
  94. Huck NA, et al. 2021. J Neurosci. 41:4349. PubMed
  95. Tang L, et al. 2021. Oncol Lett. 22:605. PubMed
  96. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  97. Clark K, et al. 2015. J Autoimmun. Available online 21 August 2015. PubMed
  98. O’Dea K, et al. 2016. PLoS One. 11:e0167801. PubMed
  99. Chen CC, et al. 2020. Cancer Cell. 37:71. PubMed
  100. Ebneter A, et al. 2017. Transl Vis Sci Technol. 10.1167/tvst.6.2.10. PubMed
  101. Chen Y, et al. 2018. EBioMedicine. 32:31. PubMed
  102. Misumi I et al. 2019. Cell Rep. 27(5):1387-1396 . PubMed
  103. Song C, et al. 2019. Nat Commun. 10:3745. PubMed
  104. Saleh MM, et al. 2019. Cell Host Microbe. 25:756. PubMed
  105. Hanhai Z, et al. 2021. Aging (Albany NY). 13:13108. PubMed
  106. Zhang J, et al. 2021. MedComm (Beijing). 2:256. PubMed
  107. Hewitson JP, et al. 2020. J Immunol. 204:2949. PubMed
  108. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  109. Boldison J, et al. 2020. Cell Mol Immunol. 17:843. PubMed
  110. de Groot AE, et al. 2021. Prostate. 81:629. PubMed
  111. Skinner DD, et al. 2022. Front Immunol. 13:931388. PubMed
  112. Pack AD, et al. 2021. Cell Reports. 36:109586. PubMed
  113. Larouche JA, et al. 2021. eLife. 0.416666666666667. PubMed
  114. Yousif AS, et al. 2020. Immunity. 54(2):235-246.e5. PubMed
  115. Elbaz M, et al. 2015. Mol Oncol. 9: 906-919. PubMed
  116. Yang Y, et al. 2020. Cell Death Discov. 0.293055556. PubMed
  117. Lutzmann M, et al. 2019. Cell Rep. 28:2851. PubMed
  118. Chow MT et al. 2019. Immunity. 50(6):1498-1512 . PubMed
  119. Chattopadhyay A, et al. 2018. Sci Rep. 8:9032. PubMed
  120. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  121. Oh DS, et al. 2021. Autophagy. 17:2111. PubMed
  122. Wang Q, et al. 2020. Wound Repair Regen. 28:105. PubMed
  123. Jia G, et al. 2022. Front Cell Dev Biol. 9:796757. PubMed
  124. Rogic A, et al. 2021. Nat Commun. 12:6889. PubMed
  125. Rossi DC, et al. 2021. J Clin Invest. 131:. PubMed
  126. Castiglioni A, et al. 2015. PLoS One. 10:128094. PubMed
  127. Nasser MW, et al. 2015. Cancer Res . 75: 974-985. PubMed
  128. Liu Y, et al. 2015. Sci Rep. 5:17215. PubMed
  129. Peng J, et al. 2016. Nat Commun. 7:12029. PubMed
  130. Seita Y, et al. 2020. J Alzheimers Dis. 75:45:00. PubMed
  131. Shi L, et al. 2021. Immunity. . PubMed
  132. Jin X, et al. 2019. Mol Cell. 73:22:00. PubMed
  133. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  134. Yamashiro LH, et al. 2020. Nat Commun. 2.806944444. PubMed
  135. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  136. Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
  137. Bae SH, et al. 2021. Theranostics. 11:2522. PubMed
  138. Mathur S, et al. 2021. JCI Insight. 6:. PubMed
  139. Kummer MP, et al. 2021. EMBO J. 40:e108662. PubMed
  140. Casali P, et al. 2021. Front Immunol. 12:761450. PubMed
  141. Xu M, et al. 2021. Front Physiol. 12:700338. PubMed
  142. Bell BJ, et al. 2022. Brain Behav Immun Health. 23:100478. PubMed
  143. Dolgova EV, et al. 2022. Int J Mol Sci. 23:. PubMed
  144. Xiong A, et al. 2022. EBioMedicine. 83:104239. PubMed
  145. Han C, et al. 2021. Cell Reports. 34(6):108706. PubMed
  146. Lebratti T, et al. 2021. eLife. 10:00. PubMed
  147. Chew W, et al. 2016. Nat Methods. 13: 868-874. PubMed
  148. Oghumu S, et al. 2014. Immunology. 143: 109-119. PubMed
  149. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  150. Sive J, et al. 2015. Leukemia. . PubMed
  151. Eddens T, et al. 2015. J Immunol. 195: 185 - 193. PubMed
  152. Haas R 2013. J Immunol. 190:3100. PubMed
  153. Zhou Z, et al. 2019. Oxid Med Cell Longev. 2019:1209307. PubMed
  154. An YA et al. 2017. eLife. 6 pii: e24071. PubMed
  155. Nowak WN, et al. 2019. Mediators Inflamm. 2019:1868170. PubMed
  156. Tran L, et al. 2017. Cancer Immunol Res. 5:1141. PubMed
  157. Nakamura‐Ishizu A et al. 2018. Cell reports. 25(7):1772-1785 . PubMed
  158. Zhang X, et al. 2022. Pharmaceutics. 14:. PubMed
  159. Higa T, et al. 2022. Nat Commun. 13:1500. PubMed
  160. Zhang Z, et al. 2021. Oncoimmunology. 10:1912472. PubMed
  161. Syed A, et al. 2015. Infect Immun . 83: 3428-3437. PubMed
  162. Gabbita S, et al. 2015. PLoS One. 10: e0137305. PubMed
  163. Zhang Y, et al. 2020. Int J Mol Sci. 21:00. PubMed
  164. Szafran BN, et al. 2021. Chemical Research in Toxicology. 34(6):1556-1571. PubMed
  165. Dos Santos Dias L, et al. 2021. PLoS Pathog. e1009324:17. PubMed
  166. McCreedy DA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed
  167. Yang L, et al. 2020. Cell Stem Cell. 27(1):125-136. PubMed
  168. Sato H, et al. 2020. Cell Reports. 31(5):107579. PubMed
  169. Gui J, et al. 2020. Nat Cancer. 1:603. PubMed
  170. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  171. Donlan AN, et al. 2020. Anaerobe. 66:102275. PubMed
  172. Hug S, et al. 2021. Front Immunol. 12:642867. PubMed
  173. Xiao P, et al. 2021. JCI Insight. 6:. PubMed
  174. Yu X, et al. 2022. J Extracell Vesicles. 11:e12185. PubMed
  175. Dane EL, et al. 2022. Nat Mater. 21:710. PubMed
  176. Zhou Y, et al. 2022. Nat Commun. 13:2906. PubMed
  177. Kumari A, et al. 2022. Sci Rep. 12:15273. PubMed
  178. Li P, et al. 2021. Nat Immunol. 22:1107. PubMed
  179. Uher O, et al. 2021. Cancers (Basel). 13:. PubMed
  180. Callahan SM, et al. 2021. Curr Protoc. 1:e294. PubMed
  181. Yoshida K, et al. 2022. Sci Rep. 12:17276. PubMed
  182. Shcherbina A, et al. 2020. Cell Rep. 32:107964. PubMed
  183. Flommersfeld S, et al. 2021. Immunity. :. PubMed
  184. Alshetaiwi H, et al. 2020. Sci Immunol. 5:00. PubMed
  185. Honarpisheh P, et al. 2020. J Neuroinflammation. 0.9625. PubMed
  186. Chun E, et al. 2020. Immunity. 51(5):871-884.e6.. PubMed
  187. Di Genua C, et al. 2020. Cancer Cell. 37(5):690-704.e8.. PubMed
  188. Domingos-Pereira S, et al. 2019. Cancer Immunol Res. 7:621. PubMed
  189. Hiramoto T, et al. 2018. Mol Ther. 26:1255. PubMed
  190. Deng Z, et al. 2017. Oncogene. 36:639. PubMed
  191. Topper MJ et al. 2017. Cell. 171(6):1284-1300 . PubMed
  192. Yu VWC, et al. 2017. Cell. 168:944. PubMed
  193. Ayoub M, et al. 2019. Sci Rep. 9:6348. PubMed
  194. Perdomo J, et al. 2019. Nat Commun. 10:1322. PubMed
  195. Yu Y, et al. 2019. J Clin Invest. 129:546. PubMed
  196. Colliou N, et al. 2018. Gut Microbes. 9:279. PubMed
  197. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  198. Hernández–Santos N, et al. 2018. Cell Host Microbe. 1.313194444. PubMed
  199. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  200. BÖiers C, et al. 2018. Dev Cell. 44:362. PubMed
  201. Kang SJ, et al. 2022. Food Sci Anim Resour. 42:903. PubMed
  202. Sodji QH, et al. 2022. Cancer Res Commun. 2:725. PubMed
  203. Li Z, et al. 2022. J Exp Clin Cancer Res. 41:74. PubMed
  204. Hu J, et al. 2022. Cell Mol Neurobiol. . PubMed
  205. Soto-Díaz K, et al. 2021. Front Immunol. 12:734349. PubMed
  206. Scheiblich H, et al. 2021. J Immunol. 207:2143. PubMed
  207. Miki Y, et al. 2016. J Biol Chem. 291: 15588 - 15601. PubMed
  208. Liu Y, et al. 2017. J Neurosci. 37(4):871-881. PubMed
  209. Li J, et al. 2020. Elife. 9:00. PubMed
  210. Wessel AW, et al. 2020. Nat Commun. 4.123611111. PubMed
  211. Callahan S, et al. 2020. Cell Microbiol. 22:e13210. PubMed
  212. Tang CC, et al. 2021. eLife. 10:00. PubMed
  213. Li Y, et al. 2020. Cell Stem Cell. 27(5):732-747.e7. PubMed
  214. Omori S, et al. 2021. Cell Reports. 34(6):108734. PubMed
  215. Derecka M, et al. 2020. Nat Immunol. 261:21. PubMed
  216. Morimura S, et al. 2021. Int J Mol Sci. :22. PubMed
  217. Socodato R, et al. 2020. Sci Signal. 13: . PubMed
  218. Peralta Ramos JM, et al. 2017. Front Immunol. 1.490277778. PubMed
  219. Deng M, et al. 2020. Nat Commun. 11:2193. PubMed
  220. Xu H, et al. 2020. Immunity. 51(4):696-708.e9.. PubMed
  221. Timmons GA, et al. 2021. Front Immunol. 12:700431. PubMed
  222. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  223. Horn KJ, et al. 2022. Nat Commun. 13:3321. PubMed
  224. Lee SS, et al. 2022. Commun Biol. 5:654. PubMed
  225. Sá da Bandeira D, et al. 2022. Cell Rep. 40:111114. PubMed
  226. Grune J, et al. 2022. Nat Cardiovasc Res. 1:649. PubMed
  227. Pitsch J, et al. 2021. Ann Neurol. 89:666. PubMed
  228. Hu J, et al. 2022. J Neuroinflammation. 19:71. PubMed
  229. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  230. Hassan AO, et al. 2021. Cell Reports. 36(4):109452. PubMed
  231. Zee BM, et al. 2021. iScience. 24(6):102651. PubMed
  232. Nguyen PT, et al. 2020. Cell. 182(2):388-403.e15. PubMed
  233. Bayik D, et al. 2020. Cancer Discov. 1.256944444. PubMed
  234. Corrales L, et al. 2016. J Immunol. 196: 3191-3198. PubMed
  235. Koshida R, et al. 2015. Biochem Biophys Res Commun. 463: 109-115. PubMed
  236. Yu LC, et al. 2020. Front Neurol. 1.104166667. PubMed
  237. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  238. Qi S et al. 2016. eLife. 5 pii: e14756. PubMed
  239. Haloul M, et al. 2019. Sci Rep. 9:14050. PubMed
  240. Booth CAG, et al. 2018. Cancer Cell. 33:274. PubMed
  241. Xu X, et al. 2018. Cell. 175:1336. PubMed
  242. Habib S, et al. 2018. Infect Immun. 86:e00019. PubMed
  243. Ishidome T et al. 2017. EBioMedicine. 22:89-99 . PubMed
  244. Zhou Z, et al. 2022. Life (Basel). 12:. PubMed
  245. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  246. Harnett MM, et al. 2022. Front Immunol. 13:953053. PubMed
  247. Yang Z, et al. 2021. Sci Adv. 7:. PubMed
  248. Shen X, et al. 2021. Front Immunol. 12:710750. PubMed
  249. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  250. Kren N, et al. 2020. Sci Rep. 10:7390. PubMed
  251. Viengkhou B, et al. 2021. J Neuroinflammation. 18:237. PubMed
  252. Cuesta M, et al. 2016. J Immunol. 196: 2466 - 2475. PubMed
  253. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  254. Nosho S, et al. 2020. Int J Mol Sci. 21:00. PubMed
  255. Runyan CE, et al. 2020. Aging Cell. 19:00. PubMed
  256. Burns JC, et al. 2020. eLife. 9:00. PubMed
  257. Tripathi H, et al. 2020. Stem Cell Rev Rep. 0.953472222. PubMed
  258. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  259. Sauma D, et al. 2017. Immunol Res. 10.1007/s12026-017-8936-9. PubMed
  260. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  261. Ruan C, et al. 2020. Brain Behav Immun. 83:180. PubMed
  262. Lu P, et al. 2021. Nat Commun. 12:1042. PubMed
  263. Bugler-Lamb AR, et al. 2021. Mol Metab. 49:101197. PubMed
  264. Zhu Y, et al. 2021. EMBO J. 40:e105320. PubMed
  265. Yan W, et al. 2021. Front Med (Lausanne). 8:752223. PubMed
  266. Kim S, et al. 2021. Elife. 10:. PubMed
  267. Germundson DL, et al. 2022. Front Allergy. 3:870513. PubMed
  268. Cilenti F, et al. 2021. Immunity. . PubMed
  269. Maruoka M, et al. 2021. Molecular Cell. 81(7):1397-1410.e9. PubMed
  270. Lee J, et al. 2020. Cell Reports. 33(13):108560. PubMed
  271. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  272. Dobson HE, et al. 2020. Mucosal Immunol. 0.901388889. PubMed
  273. Cho DS, et al. 2020. J Cachexia Sarcopenia Muscle. 1.396527778. PubMed
  274. Li X, et al. 2020. Nat Commun. 4.877777778. PubMed
  275. Liu Z, et al. 2020. Cell. 178(6):1509-1525.e19.. PubMed
  276. Yu X, et al. 2019. Nat Commun. 10:574. PubMed
  277. Xia P et al. 2018. Immunity. 48(4):688-701 . PubMed
  278. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  279. Milner MT, et al. 2022. STAR Protoc. 3:101295. PubMed
  280. Zelter T, et al. 2022. EMBO Rep. 23:e53641. PubMed
  281. Zhang X, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  282. Otvos B, et al. 2021. Clin Cancer Res. 27:2038. PubMed
  283. Tapia-Abellán A, et al. 2021. Sci Adv. 7:eabf4468. PubMed
  284. Ye X, et al. 2021. Cancer Biol Med. Online ahead of print. PubMed
  285. Huang J, et al. 2014. J Immunol. 192:1972. PubMed
  286. Xiong X, et al. 2015. Stroke. 46: 2271-2276. PubMed
  287. Zhang L, et al. 2021. iScience. 24(9):102942. PubMed
  288. Alam Z, et al. 2020. Cell Rep. 107825:31. PubMed
  289. Sun J et al. 2018. Cell stem cell. 23(3):355-369 . PubMed
  290. Goldstein JM et al. 2019. Cell reports. 27(4):1254-1264 . PubMed
  291. Ford J, et al. 2019. Front Immunol. 2.502083333. PubMed
  292. Ge C, et al. 2020. Cell Reports. 29(13):4236-4244.e3.. PubMed
  293. Akk A, et al. 2019. Mol Immunol. 114:629. PubMed
  294. Yang Y, et al. 2020. Cell Death Discov. 6:62. PubMed
  295. Li W, et al. 2021. Cell Transplant. 30:9636897211004090. PubMed
  296. Wüthrich M, et al. 2021. MBio. 12:e0201821. PubMed
  297. Vasudevan SO, et al. 2022. Cell Rep. 39:110755. PubMed
  298. Kohn EM, et al. 2022. J Immunol. 208:1417. PubMed
  299. Wolf SJ, et al. 2022. JCI Insight. 7:. PubMed
  300. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  301. Chen R, et al. 2021. Cell Reports. 34(7):108751. PubMed
  302. Lowe PP, et al. 2020. J Neuroinflammation. 0.913888889. PubMed
  303. León-Cabrera S, et al. 2014. Int J Biol Sci. 9 948 . PubMed
  304. Johansson J, et al. 2013. J Neurosci. 33:16016. PubMed
  305. Hohsfield LA, et al. 2020. J Neuroinflammation. 0.902083333. PubMed
  306. Horn LA, et al. 2017. Oncotarget. 8:57964. PubMed
  307. Tang Y, et al. 2019. Nat Commun. 10:4157. PubMed
  308. Metidji A et al. 2018. Immunity. 49(2):353-362 . PubMed
  309. Duarte D, et al. 2018. Cell Stem Cell. 22:64. PubMed
  310. Nenasheva T, et al. 2017. PLoS One. 12(6):e0178983. PubMed
  311. Ha TC, et al. 2020. Hum Gene Ther. 32:458. PubMed
  312. Howard ZM, et al. 2022. JCI Insight. 7:. PubMed
  313. Gavini CK, et al. 2022. J Neuroinflammation. 19:57. PubMed
  314. McCallion A, et al. 2022. Front Immunol. 13:961599. PubMed
  315. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  316. Mohammadi MR, et al. 2021. Commun Biol. 4:685. PubMed
  317. Gorina R, et al. 2014. J Immunol. 192:324. PubMed
  318. Liu Y, et al. 2015. BioMed Res Int. 2015 563425. PubMed
  319. Choi J, et al. 2015. PLoS One. 10: e0138592. PubMed
  320. Jaako P, et al. 2016. Leukemia. 10.1038/leu.2016.159. PubMed
  321. Kumari P, et al. 2021. Cell Reports. 35(3):109012. PubMed
  322. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
  323. Uribe-Herranz M, et al. 2018. JCI Insight. 3. PubMed
  324. Vásquez M, et al. 2019. J Immunol. 203:696. PubMed
  325. Ohgomori T et al. 2019. J Comp Neurol. 528(1):14-31 . PubMed
  326. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  327. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  328. Scheiblich H, et al. 2021. Cell. 184:5089. PubMed
  329. Deng Q, et al. 2021. Gut Microbes. 13:1. PubMed
  330. Kataru RP, et al. 2022. Front Aging. 3:864860. PubMed
  331. Woodring T, et al. 2022. iScience. 25:104934. PubMed
  332. Yang YS, et al. 2022. Nat Commun. 13:6175. PubMed
  333. Asadi Shahmirzadi A, et al. 2020. Cell Metabolism. 32(3):447-456.e6. PubMed
  334. Vaibhav K, et al. 2020. Sci Adv. 6:eaax8847. PubMed
  335. Prislovsky A, Strom T 2013. Exp Hematol. 41:789. PubMed
  336. Kajiwara C, et al. 2018. J Immunol. 200:623. PubMed
  337. Gomes T, et al. 2019. Front Immunol. 10:2088. PubMed
  338. Liu X, et al. 2021. Int J Med Sci. 18:3125. PubMed
  339. Friker LL, et al. 2020. Cell Rep. 30:3743. PubMed
  340. Chen F, et al. 2021. J Cell Mol Med. 25:11039. PubMed
  341. Howard ZM, et al. 2021. Am J Pathol. 191:730. PubMed
  342. Luciunaite A, et al. 2020. J Neurochem. 155:650. PubMed
  343. Pi J, et al. 2022. J Nanobiotechnology. 20:36. PubMed
  344. Zheng Y, et al. 2022. J Immunol. 208:501. PubMed
  345. van Geffen C, et al. 2021. Front Immunol. 12:695933. PubMed
  346. Milich LM, et al. 2021. J Exp Med. 218:. PubMed
  347. Takeda K, et al. 2014. Am J Pathol. 184:686. PubMed
  348. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  349. Cerina M, et al. 2017. Brain Behav Immun. 59:103-117. PubMed
  350. Messerer DAC, et al. 2020. Front Immunol. 11:571992. PubMed
  351. Markworth JF, et al. 2020. JCI Insight. 5:00. PubMed
  352. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  353. Chung S, et al. 2020. Am J Physiol Lung Cell Mol Physiol. L921:318. PubMed
  354. Steinkühler J, et al. 2018. J Cell Sci. 132. PubMed
  355. Haruwaka K, et al. 2019. Nat Commun. 4.455555556. PubMed
  356. Ireland L, et al. 2020. Front Immunol. 11:297. PubMed
  357. Ombrato L, et al. 2021. Nat Protoc. 16:872. PubMed
  358. Kelley WJ, et al. 2022. JCI Insight. 7: . PubMed
  359. Smith KJ, et al. 2022. PLoS Biol. 20:e3001554. PubMed
  360. Jia Y, et al. 2022. Cell Discov. 8:21. PubMed
  361. Gao P, et al. 2021. Nat Commun. 1194:12. PubMed
  362. Ubags ND, et al. 2021. J Allergy Clin Immunol. 1049:147. PubMed
  363. Hara T, et al. 2021. Cancer Cell. 39(6):779-792.e11. PubMed
  364. Riedel SS, et al. 2021. Molecular Cell. 81(11):2332-2348.e9. PubMed
  365. Simoni L, et al. 2020. Cell Rep. 33:108330. PubMed
  366. Fukasawa K, et al. 2016. Sci Rep. 6:30918. PubMed
  367. Andresen L, et al. 2016. PLoS One. 11: 0148428. PubMed
  368. Pelly V, et al. 2016. Mucosal Immunol. 10.1038/mi.2016.4. PubMed
  369. Jiang Y, et al. 2015. MBio. 6: e01426-15. PubMed
  370. Shi Y, et al. 2015. Mol Immunol. 66: 208-215. PubMed
  371. Tr änkner D, et al. 2019. Cell Rep. 29:791. PubMed
  372. Kunishita Y, et al. 2020. Front Immunol. 11:98. PubMed
  373. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  374. Nguyen HX et al. 2017. J Neurosci. 37(38):9269-9287 . PubMed
  375. Schroder WA, et al. 2019. Sci Rep. 9:12421. PubMed
  376. Wang C, et al. 2018. Sci Transl Med. 10. PubMed
  377. Nakamura K, et al. 2018. Cancer Cell. 33:634. PubMed
  378. Hao L, et al. 2021. Br J Pharmacol. 178:4726. PubMed
  379. Fan HH, et al. 2021. Methods Mol Biol. 2276:203. PubMed
  380. Chavez JS, et al. 2022. Cells. 11:. PubMed
  381. Shen L, et al. 2021. Cell Metabolism. 33(5):971-987.e6. PubMed
  382. Thurlow LR, et al. 2018. Cell Host Microbe. 24:261. PubMed
  383. Petriello MC, et al. 2018. Toxicol Sci. 162:548. PubMed
  384. Hilt ZT, et al. 2019. JCI Insight. 4:5. PubMed
  385. Ioanna E Galani et al. 2017. Immunity. 46(5):875-890 . PubMed
  386. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  387. Zhang B, et al. 2021. Nature. 599:471. PubMed
  388. Jones GS, et al. 2020. mSphere. 5:. PubMed
  389. Xiao M, et al. 2022. Mol Oncol. 16:1026. PubMed
  390. Awida Z, et al. 2021. Int J Mol Sci. 23:. PubMed
  391. Zha ZX, et al. 2022. Acta Pharmacol Sin. :. PubMed
  392. Zhang H, et al. 2022. Commun Biol. 5:916. PubMed
  393. Li J, et al. 2022. Nat Commun. 13:1481. PubMed
  394. Du Z, et al. 2020. J Allergy Clin Immunol. . PubMed
  395. Li X, et al. 2021. Cell Reports. 36(8):109607. PubMed
  396. Li J, et al. 2021. eLife. 10:00. PubMed
  397. Wan Y, et al. 2020. Cell Rep. 33:108346. PubMed
  398. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  399. Xie Y, et al. 2020. Endocrinology. 161:00:00. PubMed
  400. Hohmann A, et al. 2016. Nat Chem Biol. 10.1038/nchembio.2115. PubMed
  401. Ramos-Sevillano E, et al. 2016. PLoS One. 12: 1005500. PubMed
  402. Kolan S, et al. 2015. PLoS One. 10: 0134113. PubMed
  403. Iwata-Yoshikawa N, et al. 2014. J Virol. 88:8597. PubMed
  404. Ma Y, et al. 2020. Front Immunol. 11:586685. PubMed
  405. Guenther C, et al. 2019. Front Immunol. 10:1138. PubMed
  406. Guarnerio J, et al. 2018. Nat Commun. 9:66. PubMed
  407. Li B, et al. 2019. Oncogenesis. 8:17. PubMed
  408. Omenetti S, et al. 2019. Immunity. 51:77. PubMed
  409. Yáñez A et al. 2017. Immunity. 47(5):890-902 . PubMed
  410. Han J, et al. 2022. Cell Discov. 8:122. PubMed
  411. Schmidts A, et al. 2020. J Immunother Cancer. 8:. PubMed
  412. Sethuraman SN, et al. 2020. Theranostics. 10:3397. PubMed
  413. Hohsfield LA, et al. 2021. Elife. 10:. PubMed
  414. Zhong J, et al. 2021. Commun Biol. 4:865. PubMed
  415. Zhang J, et al. 2021. Stem Cell Res Ther. 12:579. PubMed
  416. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
  417. Ren X, et al. 2021. Cell Death Dis. 12:484. PubMed
RRID
AB_312794 (BioLegend Cat. No. 101211)
AB_312794 (BioLegend Cat. No. 101212)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
PE/Fire™ 744 anti-mouse/human CD11b M1/70 FC
Spark PLUS UV395™ anti-mouse/human CD11b M1/70 FC
Spark Red™ 718 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account