Purified anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
1-M1slash70_Purified_042706
C57BL/6 mouse bone marrow cells were stained with purified CD11b (clone M1/70) (filled histogram) or rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG FITC (gated on total cells).
  • 1-M1slash70_Purified_042706
    C57BL/6 mouse bone marrow cells were stained with purified CD11b (clone M1/70) (filled histogram) or rat IgG2b, κ isotype control (open histogram), followed by anti-rat IgG FITC (gated on total cells).
  • 2-M170_Pure_CD11b_Antibody_IHC_102418
    Fresh, frozen mouse spleen was stained with purified CD11b clone M1/70 conjugated and detected with a Cy5 CODEX™ oligonucleotide duplex (red). Samples were counterstained with TCR FITC (green). Data generated at Akoya Biosciences, Inc. using the CODEX™ technology.
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Cat # Size Price Quantity Check Availability
101201 50 µg $30.00
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101202 500 µg $114.00
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Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Technical data sheet

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F, CyTOF® - Verified
IP, ICC - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Peterson EJ, et al. 2019. Mol Syst Biol. 15:e8584. PubMed
  2. Axelrod HD, et al. 2019. Mol Cancer Res. 17:356. PubMed
  3. Tong CF, et al. 2018. Am J Physiol Cell Physiol. 315:C409. PubMed
  4. Arnold IC, et al. 2019. PLoS Pathog. 15:e1007866. PubMed
  5. Wolf Y, et al. 2017. J Exp Med. 214:905. PubMed
  6. Taki M, et al. 2018. Nat Commun. 1.545138889. PubMed
  7. Vinaik R, et al. 2019. Am J Physiol Endocrinol Metab. 317:E751. PubMed
  8. Shirai T, et al. 2022. Cancer Sci. 113:3710. PubMed
  9. Chen W, et al. 2023. JCI Insight. 8:. PubMed
  10. Wang JX, et al. 2023. JCI Insight. 8:. PubMed
  11. Kang YA, et al. 2023. J Exp Med. 220:. PubMed
  12. Diray-Arce J, et al. 2023. Cell Rep Med. 4:101079. PubMed
  13. Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed
  14. Kobayashi A, et al. 2021. Front Immunol. 12:650856. PubMed
  15. Paterson MJ, et al. 2020. PLoS Pathog. 16:e1008733. PubMed
  16. Li F, et al. 2020. EMBO J. 39:e103205. PubMed
  17. Liu CJ, et al. 2020. Neuro Oncol. 22:1276. PubMed
  18. Doll JR, et al. 2020. PLoS Pathog. 16:e1008296. PubMed
  19. Yu H, et al. 2020. Front Immunol. 11:1773. PubMed
  20. Cai S, et al. 2020. Sci Rep. 10:14249. PubMed
  21. Calcagno DM, et al. 2020. Sci Immunol. 5: . PubMed
  22. Malinczak CA, et al. 2021. J Immunol. 206:1315. PubMed
  23. Li H, et al. 2022. Cancer Cell. 40:36. PubMed
  24. Moore J, et al. 2022. Cancer Res. 82:365. PubMed
  25. Valet C, et al. 2022. J Clin Invest. 132: . PubMed
  26. Xiong T, et al. 2022. Cancer Sci. 113:1955. PubMed
  27. Campisi L, et al. 2022. Nature. 606:945. PubMed
  28. Moore AR, et al. 2022. Cell Rep. 41:111651. PubMed
  29. Zhao J, et al. 2022. J Clin Invest. 132: . PubMed
  30. Gavish A, et al. 2023. iScience. 26:105826. PubMed
  31. Jiang L, et al. 2021. Nano Today. 36:. PubMed
  32. Potempa M, et al. 2022. J Immunol. 208:1742. PubMed
  33. Kim D, et al. 2008. Blood. 112:1109. PubMed
  34. Mazor R, et al. 2018. Proc Natl Acad Sci U S A. 115:E733. PubMed
  35. Chung MI, et al. 2018. Am J Respir Cell Mol Biol. 59:706. PubMed
  36. Burrello C, et al. 2018. Front Med (Lausanne). 5:21. PubMed
  37. Chartrand K, et al. 2018. Front Immunol. 1.642361111. PubMed
  38. Shirakawa K, et al. 2017. PLoS One. 12:e0186303. PubMed
  39. Zhou LJ et al. 2019. Cell Rep. 27(13):3844-3859 . PubMed
  40. Yonemitsu K, et al. 2022. Sci Rep. 12:12007. PubMed
  41. Pilling D, et al. 2022. Respir Res. 23:215. PubMed
  42. Bajaña S, et al. 2021. Front Immunol. 11:577718. PubMed
  43. Zhao J, et al. 2021. JCI Insight. 6:. PubMed
  44. Larson-Casey JL, et al. 2021. FASEB J. 35:e21675. PubMed
  45. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  46. Reglero-Real N, et al. 2021. Immunity. :. PubMed
  47. Weidner H, et al. 2020. JCI Insight. 5:00. PubMed
  48. Bachran C, et al. 2017. Sci Rep.. 10.1038/s41598-017-17948-0. PubMed
  49. Wagner J et al. 2019. Cell. 177(5):1330-1345 . PubMed
  50. Peng J, et al. 2019. Mol Brain. 12:71. PubMed
  51. Ajona D, et al. 2017. Cancer Discov. 0.773611111. PubMed
  52. Goel S, et al. 2017. Nature. 548:471. PubMed
  53. Tang B, et al. 2019. Oncolytic Virother. 8:03. PubMed
  54. Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
  55. Arnold IC, et al. 2018. J Exp Med. 215:2055. PubMed
  56. Prado C, et al. 2021. J Neuroinflammation. 18:292. PubMed
  57. Leyva-Castillo JM, et al. 2020. Clin Immunol. 218:108511. PubMed
  58. Chen L, et al. 2019. Nat Commun. 3.553472222. PubMed
  59. Cao Q, et al. 2018. Am J Physiol Renal Physiol. 314:F561. PubMed
  60. Lechner AJ et al. 2017. Cell stem cell. 21(1):120-134 . PubMed
  61. Dertschnig S, et al. 2020. J Clin Invest. 130:1896. PubMed
  62. Dienz O, et al. 2020. J Immunol. 204:1521. PubMed
  63. Nguyen N, et al. 2022. iScience. 25:103679. PubMed
  64. Karhadkar TR, et al. 2021. J Pharmacol Exp Ther. 376:106. PubMed
  65. Rogic A, et al. 2021. Nat Commun. 12:6889. PubMed
  66. Dave K et al. 2017. eLife. 6 pii: e23382. PubMed
  67. Arimura K, et al. 2017. Mucosal Immunol. 1.08125. PubMed
  68. Liu T, et al. 2020. Sci Adv. 6:eaay1497. PubMed
  69. Bredehöft J, et al. 2022. J Inflamm Res. 15:509. PubMed
  70. Tian D, et al. 2020. FASEB J. 34:3367. PubMed
  71. Stefanescu C, et al. 2021. Front Oncol. 11:765151. PubMed
  72. Peng J, et al. 2016. Nat Commun. 7:12029. PubMed
  73. Haney MS, et al. 2018. Nat Genet. 50:1716. PubMed
  74. McLeod RL, et al. 2018. Oncotarget. 9:34459. PubMed
  75. Rissiek B, et al. 2017. Sci Rep. . 10.1038/s41598-017-16613-w. PubMed
  76. Lee JH, et al. 2022. iScience. 25:104166. PubMed
  77. Delgobo M, et al. 2021. Front Immunol. 12:584538. PubMed
  78. Tal MC, et al. 2020. MBio. 11:00. PubMed
  79. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  80. Nolin JD, et al. 2017. JCI Insight. 2:e94929. PubMed
  81. Chen S, et al. 2018. Immunohorizons. 0.345138889. PubMed
  82. Yang C, et al. 2019. MBio. 10:e00595-19. PubMed
  83. Silvestre-Roig C, et al. 2019. Nature. 569:236. PubMed
  84. Khan KA, et al. 2020. NPJ Breast Cancer. 6:29. PubMed
  85. Guiducci E, et al. 2018. Front Immunol. 1.467361111. PubMed
  86. Guo Y, et al. 2008. Blood. 112:480. PubMed
  87. Gui J, et al. 2020. Nat Cancer. 1:603. PubMed
  88. Si Y, et al. 2020. Sci Adv. 6:eaaw7713. PubMed
  89. O'Dea KP, et al. 2020. J Extracell Vesicles. 9:1706708. PubMed
  90. Matsuhira T, et al. 2021. Biochem Biophys Rep. 28:101118. PubMed
  91. Suzuki Y, et al. 2021. FEBS Open Bio. 11:2619. PubMed
  92. Yan J, et al. 2020. Cancer Immunol Res. 8:356. PubMed
  93. Gomi M, et al. 2021. Mol Ther. 29:225. PubMed
  94. Chen L, et al. 2020. Front Immunol. 11:584458. PubMed
  95. Seelige R, et al. 2018. Sci Rep. 8:13670. PubMed
  96. Zhao L, et al. 2018. Nat Med. 24:1536. PubMed
  97. Manni M, et al. 2018. Nat Immunol. 1.074305556. PubMed
  98. Stacey MA, et al. 2017. J Clin Invest. 127:1463. PubMed
  99. He LD, et al. 2021. EMBO Rep. 22:e52196. PubMed
  100. Sun Y, et al. 2022. Nat Commun. 13:3916. PubMed
  101. Karhadkar TR, et al. 2021. PLoS One. 16:e0245924. PubMed
  102. Gartlan KH, et al. 2019. Blood Adv. 2.110416667. PubMed
  103. Abboud G, et al. 2018. Front Immunol. 9:1973. PubMed
  104. Napimoga M, et al. 2008. J Immunol. 180:609. PubMed
  105. Lai JF, et al. 2020. J Allergy Clin Immunol. 146:1406. PubMed
  106. Vukman KV, et al. 2020. J Extracell Vesicles. 10:e12023. PubMed
  107. Jiang L, et al. 2022. Front Immunol. 12:730438. PubMed
  108. Sato Y, et al. 2021. BMC Cancer. 21:1222. PubMed
  109. Liu H, et al. 2020. J Immunol. 205:1207. PubMed
  110. Muraleedharan A, et al. 2021. Glia. 69:697. PubMed
  111. Bednarczyk M, et al. 2021. Int J Mol Sci. 22:. PubMed
  112. Shokirova H, et al. 2021. Sci Rep. 11:8647. PubMed
  113. Brown IK, et al. 2021. PLoS Pathog. 17:e1009602. PubMed
  114. Francis M, et al. 2017. Toxicol Sci. 155(1):182-195. PubMed
  115. Wei S, et al. 2019. Virulence. 0.588888889. PubMed
  116. Kapellos TS, et al. 2017. Mediators Inflamm. 2017:4315412. PubMed
  117. Umemoto T, et al. 2017. EMBO J. 36:2390. PubMed
  118. Kim SJ, et al. 2017. Nat Immunol. 18:1016. PubMed
  119. Tsubaki T, et al. 2018. Oncotarget. 9:11209. PubMed
  120. Wicki S, et al. 2018. Int J Mol Sci. 1.266666667. PubMed
  121. Hoves S, et al. 2018. J Exp Med. 215:859. PubMed
  122. Hakamivala A, et al. 2020. Bioact Mater. 5:142. PubMed
  123. Zhong X, et al. 2020. Proc Natl Acad Sci U S A. 8563:117. PubMed
  124. Zareie P, et al. 2017. J Neuroinflammation. 0.630555556. PubMed
  125. Lee JY, et al. 2018. Front Immunol. 0.678472222. PubMed
  126. Davies CL, et al. 2019. Front Immunol. 10:1048. PubMed
  127. Paharik AE, et al. 2017. Cell Host Microbe. 22:746. PubMed
  128. Nascimento DC, et al. 2017. Nat Commun. 8:14919. PubMed
  129. Shin J, et al. 2018. Diabetes. 67:1068. PubMed
  130. Majer O, et al. 2019. Nature. 575:366. PubMed
  131. Krueger A, et al. 2022. Front Microbiol. 12:789042. PubMed
  132. Johnson SA, et al. 2021. Eur J Immunol. 51:3228. PubMed
  133. Manabe T, et al. 2021. J Neurochem. 159:525. PubMed
  134. Schuler CF, et al. 2020. Allergy. 75:2279. PubMed
  135. Lim CS, et al. 2020. Front Immunol. 11:1186. PubMed
  136. Yoon S, et al. 2020. Antioxidants (Basel). 10:. PubMed
  137. Tao H, et al. 2021. Front Immunol. 12:623280. PubMed
  138. You X, et al. 2022. Front Genet. 12:790990. PubMed
  139. Coden ME, et al. 2020. J Immunol. 204:438. PubMed
  140. Daley D, et al. 2017. Nat Med. 23:556. PubMed
  141. Hsieh JY, et al. 2019. APL Bioeng. 3:016103. PubMed
  142. Nagatake T, et al. 2018. Int Immunol. 30:471. PubMed
  143. Chen HW, et al. 2021. Biomedicines. 9:. PubMed
  144. Karhadkar TR, et al. 2020. bioRxiv. . PubMed
  145. Huang S, et al. 2020. Cell Rep. 33:108394. PubMed
  146. Madsen D, et al. 2017. Cell Rep.. 10.1016/j.celrep.2017.12.011. PubMed
  147. Fino KK, et al. 2017. Sci Rep. 5.334722222. PubMed
  148. Yoon BH, et al. 2018. Mol Cells. 41:953. PubMed
  149. Hoffmann FM, et al. 2018. Front Immunol. 9:1046. PubMed
  150. Baumgartner C, et al. 2010. J Immunol. 184:573. PubMed
  151. Yi MH, et al. 2020. Brain Behav Immun. 92:78. PubMed
  152. Meyer-Lindemann U, et al. 2022. Front Immunol. 13:898690. PubMed
  153. Tsukui H, et al. 2020. BMC Cancer. 20:411. PubMed
  154. Li J, et al. 2021. Front Immunol. 12:710406. PubMed
  155. Kim D, et al. 2019. Immune Netw. 19:e32. PubMed
  156. Kawabe T, et al. 2017. Sci Immunol. 2:eaam9315. PubMed
  157. Nguyen CH, et al. 2020. Biomedicines. 8:. PubMed
  158. Seo SU, et al. 2021. Front Immunol. 12:697162. PubMed
  159. Speir M, et al. 2020. Nat Immunol. 21:54. PubMed
  160. Kikuchi A, et al. 2020. Am J Pathol. 190:2080. PubMed
  161. Freeman SA, et al. 2020. Science. 367:301. PubMed
  162. Galbas T, et al. 2017. J Immunol. 198(2):852-861. PubMed
  163. Akiel M, et al. 2017. Cancer Res. 77:4014. PubMed
  164. Wang Y, et al. 2019. Biomed Res Int. 2019:5756189. PubMed
  165. Roussey JA, et al. 2017. J Immunol. 199:3535. PubMed
  166. Elgazar-Carmon V, et al. 2008. J Lipid Res. 49:1849. PubMed
  167. Ding L, et al. 2022. Nanoscale. . PubMed
  168. Scortegagna M, et al. 2020. Nat Commun. 11:99. PubMed
  169. Vahsen BF, et al. 2022. Sci Rep. 12:12606. PubMed
  170. Brownlie D, et al. 2021. J Immunother Cancer. 9:. PubMed
  171. Feng L, et al. 2019. Glia. 67:1434. PubMed
  172. Wagner AK, et al. 2017. Nat Commun. 8:15627. PubMed
  173. Yamasaki T, et al. 2018. J Virol. 92:e01458. PubMed
  174. Düking T, et al. 2022. Sci Adv. 8:eabo7639. PubMed
  175. Wu W, et al. 2020. Brain Behav Immun. 89:245. PubMed
  176. Qiu Z, et al. 2022. Cancer Discov. 12:502. PubMed
  177. Link CWM, et al. 2020. Front Immunol. 11:596772. PubMed
  178. Lin Z, et al. 2021. Stem Cells. 39:240. PubMed
  179. Takeuchi Y, et al. 2021. Sci Rep. 11:18679. PubMed
  180. Lee YJ, et al. 2018. Front Microbiol. 9:83. PubMed
  181. Mohrin M, et al. 2021. Aging Cell. 20:e13313. PubMed
  182. Cané S, et al. 2021. J Immunother Cancer. 9:. PubMed
  183. Udumula MP, et al. 2021. Mol Metab. 53:101272. PubMed
  184. Nicolas-Boluda A, et al. 2021. eLife. 10:00. PubMed
  185. Olver S, et al. 2005. Cancer Res. 66:571. PubMed
  186. Cole C, et al. 2018. Nucleic Acids Res. 46:e62. PubMed
  187. Andrews AR, et al. 2019. Cancer Cell Int. 0.955555556. PubMed
  188. Diao J, et al. 2018. J Immunol. 201:1306. PubMed
  189. Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed
  190. Ortiz A, et al. 2019. Cancer Cell. 35:33:00. PubMed
  191. Winter C, et al. 2018. Cell Metab. 28:175. PubMed
  192. Stotesbury C, et al. 2020. Aging Cell. 19:e13170. PubMed
  193. Wen J, et al. 2021. PLoS Pathog. 17:e1009738. PubMed
  194. Murenu E, et al. 2021. Mol Ther Methods Clin Dev. 20:587. PubMed
  195. Murenu E, et al. 2021. Int J Mol Sci. 22:. PubMed
  196. Karuppuchamy T, et al. 2020. Inflamm Bowel Dis. 216:26. PubMed
  197. Aikawa S, et al. 2020. Cell Death Differ. 1489:27. PubMed
  198. Heib T, et al. 2021. Cell Reports. 35(6):109102. PubMed
  199. Chevrier S, et al. 2021. Cell Reports Medicine. 2(1):100166. PubMed
  200. Rossnagl S, et al. 2016. PLoS Biol. 14: 1002562. PubMed
  201. Sun Y, et al. 2015. Proc Natl Acad Sci U S A. 112: 10401-10406. PubMed
  202. An Y et al. 2018. Cell reports. 25(3):702-714 . PubMed
  203. Chevrier S, et al. 2018. Cell Syst. 0.675. PubMed
  204. Kikuchi K, et al. 2018. J Immunol. 201:635. PubMed
  205. Larson–Casey JL, et al. 2019. J Clin Invest. 129:4962. PubMed
  206. Zhang J, et al. 2019. Onco Targets Ther. 12:4985. PubMed
  207. Zheng C, et al. 2021. J Extracell Vesicles. 10:e12109. PubMed
  208. Song M, et al. 2020. Nat Commun. 11:6298. PubMed
  209. Dubik M, et al. 2021. Front Neurosci. 15:682451. PubMed
  210. Hsieh YL, et al. 2019. Cell Reports. 29(8):2134-2143.e7. PubMed
  211. Kang SH, et al. 2018. Oncoimmunology. 8:e1515057. PubMed
  212. Shao Y, et al. 2017. Onco Targets Ther. 10:2675. PubMed
  213. Fritz Y, et al. 2017. J Invest Dermatol. 137:696. PubMed
  214. Ito Y, et al. 2018. J Exp Med. 215:2617. PubMed
  215. Regan–Komito D, et al. 2017. Front Immunol. 1.459027778. PubMed
  216. He X, et al. 2017. Cancer Biol Ther. 0.815277778. PubMed
  217. Torika N, et al. 2018. CNS Neurosci Ther. 24:231. PubMed
  218. Zhou N et al. 2018. Protein & cell. 10(2):87-103 . PubMed
  219. Kästele V, et al. 2021. Mucosal Immunol. 14:717. PubMed
  220. Flores I, et al. 2021. Hum Mol Genet. Online ahead of print. PubMed
  221. Li Y, et al. 2021. Life Sci Alliance. 4:. PubMed
  222. Prabakaran T, et al. 2021. EBioMedicine. 66:103314. PubMed
  223. Li X, et al. 2020. J Clin Invest. 130:4182. PubMed
RRID
AB_312784 (BioLegend Cat. No. 101201)
AB_312784 (BioLegend Cat. No. 101202)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
PE/Fire™ 744 anti-mouse/human CD11b M1/70 FC
Spark PLUS UV395™ anti-mouse/human CD11b M1/70 FC
Spark Red™ 718 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Go To Top Version: 4    Revision Date: 12/13/2019

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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