Biotin anti-mouse CD104 Antibody anti-CD104

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Clone: 346-11A (See other available formats)
Regulatory Status: RUO
Other Names: Integrin β4, β4 integrin, TSP-1180, ITGB4
Isotype: Rat IgG2a, κ
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Product Citations: publications

346-11A_Biotin_032808 — Mouse lung carcinoma cell line (Line 1) stained with biotinylated 346-11A, followed by Sav-PE.

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123603

50 µg

$89

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Description

CD104 is a 205 kD type I transmembrane glycoprotein, also known as integrin β4 chain or β4 integrin, that associates with integrin α6 (CD49f) to form the α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells, and a subset of pre-T cells. The CD49f/CD104 heterodimer is an adhesion receptor for laminins (especially laminin 5) and keratin filaments, and is involved in the regulation of hemidesmosome formation and cell proliferation and activation.

Product Details

Technical data sheet

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Tumor-associated antigen TSP-180 from BALB/c lung carcinoma
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Additional reported (for the relevant formats) applications include: immunohistochemical staining¹.
RRID: AB_961034 (BioLegend Cat. No. 123603)

Antigen Details

Structure: Integrin β chain, 205 kD, forms heterodimer with integrin α6 (CD49f)
Distribution: Epithelial cells, endothelial cells, some tumor cells, pre-T cell subset
Function: Adhesion
Ligand/Receptor: Laminins, keratin filaments
Cell Type: Embryonic Stem Cells, Endothelial cells, Epithelial cells, T cells
Biology Area: Cell Adhesion, Cell Biology, Immunology, Stem Cells
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Kennel SJ, et al. 1992. J. Cell Sciences 101:1992.
Gene ID: 192897 View all products for this Gene ID
UniProt: View information about CD104 on UniProt.org

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Related Protocols

Cell Surface Flow Cytometry Staining Protocol

Related Products

Description	Clone	Applications

Related Pages & Pathways

Pathways

Related FAQs

How many biotin molecules are per antibody structure?: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.

Other Formats

View All CD104 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-mouse CD104	346-11A	FC,IP,ELISA
Biotin anti-mouse CD104	346-11A	FC
FITC anti-mouse CD104	346-11A	FC
Alexa Fluor® 647 anti-mouse CD104	346-11A	FC
PE anti-mouse CD104	346-11A	FC
PerCP/Cyanine5.5 anti-mouse CD104	346-11A	FC
PE/Cyanine7 anti-mouse CD104	346-11A	FC
APC anti-mouse CD104	346-11A	FC
TotalSeq™-C1028 anti-mouse CD104	346-11A	PG
TotalSeq™-B1028 anti-mouse CD104	346-11A	PG

Certificate of Analysis

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Go To Top Version: 3 Revision Date: 06/20/2018

For Research Use Only. Not for diagnostic or therapeutic use.

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